Exposure to Perfluoroalkyl Substances and Associations with Pubertal Onset and Serum Reproductive Hormones in a Longitudinal Study of Young Girls in Greater Cincinnati and the San Francisco Bay Area.
Journal
Environmental health perspectives
ISSN: 1552-9924
Titre abrégé: Environ Health Perspect
Pays: United States
ID NLM: 0330411
Informations de publication
Date de publication:
09 2023
09 2023
Historique:
medline:
28
9
2023
pubmed:
26
9
2023
entrez:
26
9
2023
Statut:
ppublish
Résumé
Per- and polyfluoroalkyl substances (PFAS), endocrine disrupting chemicals with worldwide exposure, cause changes in mammary gland development in rodents. A few human studies report delay in pubertal events with increasing perfluorooctanoic acid (PFOA) exposure, but to our knowledge none have examined reproductive hormone levels at thelarche. In a cohort of Greater Cincinnati (GC) and San Francisco Bay Area (SFBA) girls recruited at 6-8 years of age, clinical examinations were conducted annually or semiannually with sequential Tanner staging. PFAS concentrations were measured in the first serum sample of 704 girls. In 304 GC girls, estradiol ( Median PFOA serum concentrations in GC ( In multivariable Cox proportional hazard models [adjusted for race, body mass index (BMI)], increasing serum log-transformed PFOA was associated with a delay in pubarche [ PFAS may delay pubertal onset through the intervening effects on BMI and reproductive hormones. The decreases in DHEAS and
Sections du résumé
BACKGROUND
Per- and polyfluoroalkyl substances (PFAS), endocrine disrupting chemicals with worldwide exposure, cause changes in mammary gland development in rodents. A few human studies report delay in pubertal events with increasing perfluorooctanoic acid (PFOA) exposure, but to our knowledge none have examined reproductive hormone levels at thelarche.
METHODS
In a cohort of Greater Cincinnati (GC) and San Francisco Bay Area (SFBA) girls recruited at 6-8 years of age, clinical examinations were conducted annually or semiannually with sequential Tanner staging. PFAS concentrations were measured in the first serum sample of 704 girls. In 304 GC girls, estradiol (
RESULTS
Median PFOA serum concentrations in GC (
POPULATION
In multivariable Cox proportional hazard models [adjusted for race, body mass index (BMI)], increasing serum log-transformed PFOA was associated with a delay in pubarche [
CONCLUSIONS
PFAS may delay pubertal onset through the intervening effects on BMI and reproductive hormones. The decreases in DHEAS and
Identifiants
pubmed: 37751325
doi: 10.1289/EHP11811
pmc: PMC10521915
doi:
Substances chimiques
perfluorooctanesulfonamide
80AM718FML
perfluorooctanoic acid
947VD76D3L
Fluorocarbons
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
97009Subventions
Organisme : NIEHS NIH HHS
ID : U01 ES012770
Pays : United States
Organisme : NCRR NIH HHS
ID : UL1 RR024131
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES029133
Pays : United States
Organisme : NIEHS NIH HHS
ID : U01 ES012801
Pays : United States
Organisme : NIEHS NIH HHS
ID : U01 ES019453
Pays : United States
Organisme : NIEHS NIH HHS
ID : U01 ES019457
Pays : United States
Organisme : NIEHS NIH HHS
ID : T32 ES010957
Pays : United States
Organisme : NIEHS NIH HHS
ID : U01 ES019435
Pays : United States
Organisme : NCRR NIH HHS
ID : UL1 RR026314
Pays : United States
Commentaires et corrections
Type : CommentIn
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