Large-scale momentary brain co-activation patterns are associated with hyperalgesia and mediate focal neurochemistry and cross-network functional connectivity in fibromyalgia.
Journal
Pain
ISSN: 1872-6623
Titre abrégé: Pain
Pays: United States
ID NLM: 7508686
Informations de publication
Date de publication:
01 Dec 2023
01 Dec 2023
Historique:
received:
09
03
2022
accepted:
02
05
2023
medline:
17
11
2023
pubmed:
26
9
2023
entrez:
26
9
2023
Statut:
ppublish
Résumé
Fibromyalgia has been characterized by augmented cross-network functional communication between the brain's sensorimotor, default mode, and attentional (salience/ventral and dorsal) networks. However, the underlying mechanisms of these aberrant communication patterns are unknown. In this study, we sought to understand large-scale topographic patterns at instantaneous timepoints, known as co-activation patterns (CAPs). We found that a sustained pressure pain challenge temporally modulated the occurrence of CAPs. Using proton magnetic resonance spectroscopy, we found that greater basal excitatory over inhibitory neurotransmitter levels within the anterior insula orchestrated higher cross-network connectivity between the anterior insula and the default mode network through lower occurrence of a CAP encompassing the attentional networks during sustained pain. Moreover, we found that hyperalgesia in fibromyalgia was mediated through increased occurrence of a CAP encompassing the sensorimotor network during sustained pain. In conclusion, this study elucidates the role of momentary large-scale topographic brain patterns in shaping noxious information in patients with fibromyalgia, while laying the groundwork for using precise spatiotemporal dynamics of the brain for the potential development of therapeutics.
Identifiants
pubmed: 37751539
doi: 10.1097/j.pain.0000000000002973
pii: 00006396-990000000-00413
pmc: PMC10652715
mid: NIHMS1900712
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2737-2748Subventions
Organisme : NICHD NIH HHS
ID : P50 HD103538
Pays : United States
Organisme : NIDDK NIH HHS
ID : F99 DK126121
Pays : United States
Organisme : NCCIH NIH HHS
ID : R01 AT007550
Pays : United States
Organisme : NIBIB NIH HHS
ID : P41 EB015909
Pays : United States
Organisme : NIBIB NIH HHS
ID : R01 EB016089
Pays : United States
Informations de copyright
Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the International Association for the Study of Pain.
Références
Pain. 2019 Apr;160(4):833-843
pubmed: 30531308
Cell Rep. 2021 May 4;35(5):109081
pubmed: 33951427
J Rheumatol. 2011 Jun;38(6):1113-22
pubmed: 21285161
Brain Struct Funct. 2016 Nov;221(8):4203-4219
pubmed: 26669874
Neuron. 2013 Aug 21;79(4):798-813
pubmed: 23972601
Front Physiol. 2012 Feb 08;3:15
pubmed: 22347863
Pain. 2020 Jul;161(7):1555-1564
pubmed: 31990749
Neuron. 2019 Mar 6;101(5):783-800
pubmed: 30844399
Expert Rev Neurother. 2009 May;9(5):745-58
pubmed: 19402782
J Neurophysiol. 2011 Sep;106(3):1125-65
pubmed: 21653723
Proc Natl Acad Sci U S A. 2013 Mar 12;110(11):4392-7
pubmed: 23440216
Arthritis Rheum. 2012 Feb;64(2):579-83
pubmed: 21913179
Pain. 2016 Sep;157(9):1933-1945
pubmed: 27101425
Nat Rev Neurosci. 2015 Jan;16(1):55-61
pubmed: 25406711
Nature. 2008 Jun 12;453(7197):869-78
pubmed: 18548064
Front Neuroinform. 2011 Aug 22;5:13
pubmed: 21897815
Arthritis Rheumatol. 2021 Jul;73(7):1318-1328
pubmed: 33314799
Pain. 2016 Oct;157(10):2194-2207
pubmed: 27218870
PLoS Comput Biol. 2017 Feb 23;13(2):e1005350
pubmed: 28231282
J Pain. 2016 Jan;17(1):1-13
pubmed: 26456676
Pain. 2019 Jul;160(7):1594-1605
pubmed: 30839429
NMR Biomed. 2001 Jun;14(4):260-4
pubmed: 11410943
Neuroimage. 2007 Aug 1;37(1):90-101
pubmed: 17560126
J Magn Reson Imaging. 2014 Dec;40(6):1445-52
pubmed: 25548816
Front Neurosci. 2018 Feb 02;12:46
pubmed: 29456491
Nat Methods. 2019 Jan;16(1):111-116
pubmed: 30532080
JAMA. 2014 Apr 16;311(15):1547-55
pubmed: 24737367
Arthritis Rheum. 2002 May;46(5):1333-43
pubmed: 12115241
Neuroimage. 1999 Feb;9(2):179-94
pubmed: 9931268
Magn Reson Med. 2000 Jul;44(1):162-7
pubmed: 10893535
Neuroimage. 2013 Jan 1;64:112-9
pubmed: 23000786
Arthritis Rheumatol. 2022 Apr;74(4):700-710
pubmed: 34725971
Neuroimage. 2018 Oct 15;180(Pt B):485-494
pubmed: 29355767
Pain. 2013 Jan;154(1):24-33
pubmed: 23111164
Proc Natl Acad Sci U S A. 2005 Jul 5;102(27):9673-8
pubmed: 15976020
Ann Acad Med Singap. 1994 Mar;23(2):129-38
pubmed: 8080219
Arthritis Rheum. 2010 Aug;62(8):2545-55
pubmed: 20506181
Philos Trans R Soc Lond B Biol Sci. 2005 May 29;360(1457):1001-13
pubmed: 16087444
J Pain. 2014 Aug;15(8):815-826.e1
pubmed: 24815079
Anesth Analg. 2006 Oct;103(4):975-82
pubmed: 17000815
IEEE Trans Med Imaging. 2010 Jun;29(6):1310-20
pubmed: 20378467
Neuroimage. 2002 Oct;17(2):825-41
pubmed: 12377157
Lancet. 2021 May 29;397(10289):2098-2110
pubmed: 34062144
Neuroimage. 2009 Oct 15;48(1):63-72
pubmed: 19573611
PLoS One. 2015 Apr 02;10(3):e0121945
pubmed: 25835001
Neuroscience. 2016 Dec 3;338:114-129
pubmed: 27291641
Sci Adv. 2020 Mar 11;6(11):eaaz0087
pubmed: 32195349
Med Image Anal. 2008 Feb;12(1):26-41
pubmed: 17659998
NMR Biomed. 1998 Oct;11(6):266-72
pubmed: 9802468
EGEMS (Wash DC). 2013 Aug 02;1(1):1015
pubmed: 25848562
Pain. 2019 Apr;160(4):973-983
pubmed: 30763287
Neuroimage. 2018 Apr 15;170:332-347
pubmed: 28219775
Arthritis Rheumatol. 2015 May;67(5):1395-1405
pubmed: 25622796
Magn Reson Med. 2006 Jun;55(6):1219-26
pubmed: 16688703
Arthritis Rheum. 2009 Oct;60(10):3146-52
pubmed: 19790053
Hum Brain Mapp. 2019 Jun 1;40(8):2358-2376
pubmed: 30666750