Lymph node dendritic cells harbor inducible replication-competent HIV despite years of suppressive ART.

Animals Humans HIV Infections Simian Acquired Immunodeficiency Syndrome CD4-Positive T-Lymphocytes Anti-Retroviral Agents / therapeutic use Simian Immunodeficiency Virus Lymph Nodes Dendritic Cells
HIV HIV cure HIV persistence HIV reservoir HIV single-genome sequencing T follicular helper cells dendritic cells intact HIV lymph node replication-competent virus

Journal

Cell host & microbe
ISSN: 1934-6069
Titre abrégé: Cell Host Microbe
Pays: United States
ID NLM: 101302316

Informations de publication

Date de publication:
11 10 2023
Historique:
received: 13 02 2023
revised: 02 06 2023
accepted: 30 08 2023
medline: 29 11 2023
pubmed: 27 9 2023
entrez: 26 9 2023
Statut: ppublish

Résumé

Although gut and lymph node (LN) memory CD4 T cells represent major HIV and simian immunodeficiency virus (SIV) tissue reservoirs, the study of the role of dendritic cells (DCs) in HIV persistence has long been limited to the blood due to difficulties to access lymphoid tissue samples. In this study, we show that LN migratory and resident DC subpopulations harbor distinct phenotypic and transcriptomic profiles. Interestingly, both LN DC subpopulations contain HIV intact provirus and inducible replication-competent HIV despite the expression of the antiviral restriction factor SAMHD1. Notably, LN DC subpopulations isolated from HIV-infected individuals treated for up to 14 years are transcriptionally silent but harbor replication-competent virus that can be induced upon TLR7/8 stimulation. Taken together, these results uncover a potential important contribution of LN DCs to HIV infection in the presence of ART.

Identifiants

DOI: 10.1016/j.chom.2023.08.020 PMID: 37751747
pubmed: 37751747
pii: S1931-3128(23)00345-1
doi: 10.1016/j.chom.2023.08.020
pii:
doi:

Substances chimiques

Anti-Retroviral Agents 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1714-1731.e9

Subventions

Organisme : NIAID NIH HHS
ID : UM1 AI164560
Pays : United States

Informations de copyright

Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests The authors declare no competing interests.

Auteurs

Riddhima Banga (R)

Services of Immunology and Allergy, Lausanne University Hospital, University of Lausanne, 1011 Lausanne, Switzerland.

Francesco Andrea Procopio (FA)

Services of Immunology and Allergy, Lausanne University Hospital, University of Lausanne, 1011 Lausanne, Switzerland.

Erica Lana (E)

Services of Immunology and Allergy, Lausanne University Hospital, University of Lausanne, 1011 Lausanne, Switzerland.

Gregory T Gladkov (GT)

Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.

Isabelle Roseto (I)

Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.

Elizabeth M Parsons (EM)

Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA; Infectious Disease Division, Brigham and Women's Hospital, Boston, MA, USA.

Xiaodong Lian (X)

Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA; Infectious Disease Division, Brigham and Women's Hospital, Boston, MA, USA.

Marie Armani-Tourret (M)

Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.

Maxime Bellefroid (M)

Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.

Ce Gao (C)

Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.

Annamaria Kauzlaric (A)

Translational Bioinformatics and Statistics Department of Oncology, University of Lausanne Swiss Cancer Center, Lausanne, Switzerland.

Mathilde Foglierini (M)

Services of Immunology and Allergy, Lausanne University Hospital, University of Lausanne, 1011 Lausanne, Switzerland.

Oscar Alfageme-Abello (O)

Services of Immunology and Allergy, Lausanne University Hospital, University of Lausanne, 1011 Lausanne, Switzerland.

Susanna H M Sluka (SHM)

Newborn Screening Switzerland, University Children's Hospital Zurich, University of Zurich, Zurich, Switzerland.

Olivia Munoz (O)

Services of Immunology and Allergy, Lausanne University Hospital, University of Lausanne, 1011 Lausanne, Switzerland.

Andrea Mastrangelo (A)

Services of Immunology and Allergy, Lausanne University Hospital, University of Lausanne, 1011 Lausanne, Switzerland.

Craig Fenwick (C)

Services of Immunology and Allergy, Lausanne University Hospital, University of Lausanne, 1011 Lausanne, Switzerland.

Yannick Muller (Y)

Services of Immunology and Allergy, Lausanne University Hospital, University of Lausanne, 1011 Lausanne, Switzerland.

Catherine Gerald Mkindi (CG)

Ifakara Health Institute, Bagamoyo, United Republic of Tanzania; Department of Medical Parasitology and Infection Biology, Clinical Immunology Unit, Swiss Tropical and Public Health Institute, Basel, Switzerland.

Claudia Daubenberger (C)

Department of Medical Parasitology and Infection Biology, Clinical Immunology Unit, Swiss Tropical and Public Health Institute, Basel, Switzerland; University of Basel, 4001 Basel, Switzerland.

Matthias Cavassini (M)

Services of Infectious Diseases, Lausanne University Hospital, University of Lausanne, 1011 Lausanne, Switzerland.

Rafael Trunfio (R)

Services of Vascular Surgery, Lausanne University Hospital, University of Lausanne, 1011 Lausanne, Switzerland.

Sébastien Déglise (S)

Services of Vascular Surgery, Lausanne University Hospital, University of Lausanne, 1011 Lausanne, Switzerland.

Jean-Marc Corpataux (JM)

Services of Vascular Surgery, Lausanne University Hospital, University of Lausanne, 1011 Lausanne, Switzerland.

Mauro Delorenzi (M)

Translational Bioinformatics and Statistics Department of Oncology, University of Lausanne Swiss Cancer Center, Lausanne, Switzerland.

Mathias Lichterfeld (M)

Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA; Infectious Disease Division, Brigham and Women's Hospital, Boston, MA, USA.

Giuseppe Pantaleo (G)

Services of Immunology and Allergy, Lausanne University Hospital, University of Lausanne, 1011 Lausanne, Switzerland; Swiss Vaccine Research Institute, Lausanne University Hospital, University of Lausanne, 1011 Lausanne, Switzerland.

Matthieu Perreau (M)

Services of Immunology and Allergy, Lausanne University Hospital, University of Lausanne, 1011 Lausanne, Switzerland. Electronic address: matthieu.perreau@chuv.ch.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Lymph node dendritic cells harbor inducible...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Lymph node dendritic cells harbor inducible...
questionsmedicales.fr › Maladies du système immunitaire › Déficits immunitaires › Infections à VIH › Lymph node dendritic cells harbor inducible...
questionsmedicales.fr › Maladies de l'animal › Maladies des primates › Maladies des singes › Syndrome d'immunodéficience acquise du singe › Lymph node dendritic cells harbor inducible...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD4+ › Lymph node dendritic cells harbor inducible...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antiviraux › Antirétroviraux › Lymph node dendritic cells harbor inducible...
questionsmedicales.fr › Virus › Virus à ARN › Retroviridae › Rétrovirus simiens › Virus de l'immunodéficience simienne › Lymph node dendritic cells harbor inducible...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Système lymphatique › Tissu lymphoïde › Noeuds lymphatiques › Lymph node dendritic cells harbor inducible...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Système phagocytaire mononucléé › Cellules dendritiques › Lymph node dendritic cells harbor inducible...