PFAS Exposures and the Human Metabolome: A Systematic Review of Epidemiological Studies.
Endocrine-disrupting chemicals
Human metabolome
Metabolomics
PFAS
Systematic review
Journal
Current pollution reports
ISSN: 2198-6592
Titre abrégé: Curr Pollut Rep
Pays: Switzerland
ID NLM: 101731263
Informations de publication
Date de publication:
Sep 2023
Sep 2023
Historique:
medline:
27
9
2023
pubmed:
27
9
2023
entrez:
27
9
2023
Statut:
ppublish
Résumé
There is a growing interest in understanding the health effects of exposure to per- and polyfluoroalkyl substances (PFAS) through the study of the human metabolome. In this systematic review, we aimed to identify consistent findings between PFAS and metabolomic signatures. We conducted a search matching specific keywords that was independently reviewed by two authors on two databases (EMBASE and PubMed) from their inception through July 19, 2022 following PRISMA guidelines. We identified a total of 28 eligible observational studies that evaluated the associations between 31 different PFAS exposures and metabolomics in humans. The most common exposure evaluated was legacy long-chain PFAS. Population sample sizes ranged from 40 to 1,105 participants at different stages across the lifespan. A total of 19 studies used a non-targeted metabolomics approach, 7 used targeted approaches, and 2 included both. The majority of studies were cross-sectional ( Most frequently reported associations across studies were observed between PFAS and amino acids, fatty acids, glycerophospholipids, glycerolipids, phosphosphingolipids, bile acids, ceramides, purines, and acylcarnitines. Corresponding metabolic pathways were also altered, including lipid, amino acid, carbohydrate, nucleotide, energy metabolism, glycan biosynthesis and metabolism, and metabolism of cofactors and vitamins. We found consistent evidence across studies indicating PFAS-induced alterations in lipid and amino acid metabolites, which may be involved in energy and cell membrane disruption.
Identifiants
pubmed: 37753190
doi: 10.1007/s40726-023-00269-4
pmc: PMC10520990
mid: NIHMS1918423
doi:
Types de publication
Journal Article
Langues
eng
Pagination
510-568Subventions
Organisme : NIEHS NIH HHS
ID : P30 ES023515
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES033688
Pays : United States
Organisme : NIEHS NIH HHS
ID : R21 ES029328
Pays : United States
Déclaration de conflit d'intérêts
Conflict of Interest The authors declared no conflicts of interest.
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