Diagnosis and management of vulvar Darier disease: A case report.
Acantholysis
Darier disease
Retinoids
Steroids
Vulva
Journal
Case reports in women's health
ISSN: 2214-9112
Titre abrégé: Case Rep Womens Health
Pays: Netherlands
ID NLM: 101682122
Informations de publication
Date de publication:
Sep 2023
Sep 2023
Historique:
received:
20
06
2023
revised:
14
09
2023
accepted:
15
09
2023
medline:
27
9
2023
pubmed:
27
9
2023
entrez:
27
9
2023
Statut:
epublish
Résumé
Darier disease is an autosomal dominant disorder with hyperkeratotic papules affecting primarily seborrheic areas of the upper chest, back, forehead, scalp, nasolabial folds, ears, and, less frequently, the oral mucosa. A typical eruption consists of keratotic and crusted skin-colored papules and plaques. Pruritus occurs in 80% of patients, and pain is rare. Lesions can be triggered by exposure to ultraviolet light, heat, or stress. Secondary infections of the lesions are a common complication. A definitive diagnosis is obtained by a biopsy showing histological features such as acantholysis, suprabasal clefts, and "corps rond and grains". Here we present a 37-year-old woman admitted to the gynecology department with pruritic lesions she had noticed on her vulva and perineum for three months. A vulvar biopsy led to the diagnosis of Darier disease. She was referred to the dermatology department and treated with oral acitretin since systemic retinoids are offered as the first-line treatment of the disease.
Identifiants
pubmed: 37753222
doi: 10.1016/j.crwh.2023.e00545
pii: S2214-9112(23)00069-3
pmc: PMC10518574
doi:
Types de publication
Case Reports
Langues
eng
Pagination
e00545Informations de copyright
© 2023 The Authors. Published by Elsevier B.V.
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