Diencephalic Syndrome: Misleading Clinical Onset of Low-Grade Glioma.
diencephalic syndrome
failure to thrive
low-grade glioma
Journal
Current oncology (Toronto, Ont.)
ISSN: 1718-7729
Titre abrégé: Curr Oncol
Pays: Switzerland
ID NLM: 9502503
Informations de publication
Date de publication:
13 09 2023
13 09 2023
Historique:
received:
15
05
2023
revised:
26
06
2023
accepted:
08
07
2023
medline:
4
10
2023
pubmed:
27
9
2023
entrez:
27
9
2023
Statut:
epublish
Résumé
Diencephalic Syndrome is an atypical early manifestation of low-grade gliomas; so, it is important to detect it in patients that experience a failure to thrive despite adequate length growth and food intake. The purpose of this article is to focus attention on this rare but potentially dangerous cause of poor weight gain or stunting in childhood. We describe four patients with Diencephalic Syndrome and low-grade gliomas who were evaluated in our institution from January 2017 to December 2021. two patients presented with suspected malabsorption, and two presented with a suspected eating disorder. In all cases, neurological symptoms appeared late, explaining the reason for the diagnostic delay, which impacts negatively on prognosis and on quality of life. Currently, patients 1 and 2 have stable disease in second-line therapy, patient 3 has stable disease post end of second-line therapy, and patient 4 has stable disease in first-line therapy. Everyone is in psychophysical rehabilitation. A multidisciplinary evaluation is essential in order to make an early diagnosis and improve prognosis and quality of life.
Sections du résumé
BACKGROUND
Diencephalic Syndrome is an atypical early manifestation of low-grade gliomas; so, it is important to detect it in patients that experience a failure to thrive despite adequate length growth and food intake. The purpose of this article is to focus attention on this rare but potentially dangerous cause of poor weight gain or stunting in childhood.
MATERIALS AND METHODS
We describe four patients with Diencephalic Syndrome and low-grade gliomas who were evaluated in our institution from January 2017 to December 2021.
CASE DESCRIPTION AND RESULTS
two patients presented with suspected malabsorption, and two presented with a suspected eating disorder. In all cases, neurological symptoms appeared late, explaining the reason for the diagnostic delay, which impacts negatively on prognosis and on quality of life. Currently, patients 1 and 2 have stable disease in second-line therapy, patient 3 has stable disease post end of second-line therapy, and patient 4 has stable disease in first-line therapy. Everyone is in psychophysical rehabilitation.
CONCLUSIONS
A multidisciplinary evaluation is essential in order to make an early diagnosis and improve prognosis and quality of life.
Identifiants
pubmed: 37754525
pii: curroncol30090610
doi: 10.3390/curroncol30090610
pmc: PMC10529672
doi:
Types de publication
Case Reports
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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