Depletion of dexamethasone in cattle: Food safety study in dairy and beef cattle.
cattle
depletion
dexamethasone
extra-label
withdrawal intervals
Journal
Journal of veterinary pharmacology and therapeutics
ISSN: 1365-2885
Titre abrégé: J Vet Pharmacol Ther
Pays: England
ID NLM: 7910920
Informations de publication
Date de publication:
26 Sep 2023
26 Sep 2023
Historique:
revised:
22
08
2023
received:
21
06
2023
accepted:
12
09
2023
medline:
27
9
2023
pubmed:
27
9
2023
entrez:
27
9
2023
Statut:
aheadofprint
Résumé
Dexamethasone is approved for cattle in Canada for several conditions, but no withdrawal times are currently provided on the approved labels. Recently, the list of Maximum Residues Limits for Veterinary Drugs in Foods in Canada was amended to include dexamethasone. The objectives of this study were to determine the residue depletion profile of dexamethasone after an extra-label dosage regimen in milk of healthy lactating dairy cattle (n = 18) and in edible tissues of healthy beef cattle (n = 16) and to suggest withdrawal intervals. Dexamethasone was administered intramuscularly at 0.05 mg/kg daily for 3 days. Milk samples were collected prior to treatment and every 12 h up to 96 h post-dose. Muscle, liver, kidney, and peri-renal fat tissues were collected from beef cattle at 3, 7, 11, or 15 days post-dose. Dexamethasone analysis was performed by liquid chromatography/mass spectrophotometry. Dexamethasone residues were detected in milk samples up to 36 h. Muscle and fat had no detectable dexamethasone residues while kidney and liver had detectable residues only on day 3 post-dose. A withdrawal interval of 48 h for milk in Canadian dairy cattle and 7 days for meat in Canadian beef cattle are suggested for the dexamethasone treatment regimen most commonly requested to CgFARAD™.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Beef Farmers of Ontario
Organisme : Dairy Farmers of Ontario
Organisme : Ontario Ministry of Agriculture, Food and Rural Affairs
Informations de copyright
© 2023 The Authors. Journal of Veterinary Pharmacology and Therapeutics published by John Wiley & Sons Ltd.
Références
Abraham, G., Gottschalk, J., & Ungemach, F. R. (2004). Possible role of dexamethasone in sensitizing the beta-2-adrenergic receptor system in vivo in calves during concomitant treatment with clenbuterol. Pharmacology, 72(3), 196-204.
Caloni, F., Belloli, C., Crescenzo, G., Ormas, P., & Archimbault, P. (2000). Determination of dexamethasone in milk of dairy cows by immuno-enzymatic assay. Veterinary and Human Toxicology, 42(6), 345-348.
Cannizzo, F. T., Capra, P., Divari, S., Ciccotelli, V., Biolatti, B., & Vincenti, M. (2011). Effects of low-dose dexamethasone and prednisolone long term administration in beef calf: chemical and morphological investigation. Analytica Chimica Acta, 700(1-2), 95-104.
Cantiello, M., Giantin, M., Carletti, M., Lopparelli, R. M., Capolongo, F., Lasserre, F., Bollo, E., Nebbia, C., Martin, P. G., Pineau, T., & Dacasto, M. (2009). Effects of dexamethasone, administered for growth promoting purposes, upon the hepatic cytochrome P450 3A expression in the veal calf. Biochemical Pharmacology, 77(3), 451-463.
Codex Alimentarius. (2022). Maximum Residue Limits for Dexamethasone. https://www.fao.org/fao-who-codexalimentarius/codex-texts/dbs/vetdrugs/veterinary-drug-detail/en/?d_id=20
Courtheyn, D., Le Bizec, B., Brambilla, G., De Brabander, H. F., Cobbaert, E., Van de Wiele, M., & De Wasch, K. (2002). Recent developments in the use and abuse of growth promoters. Analytica Chimica Acta, 473(1), 71-82.
Fairclough, R. J., Hunter, J. T., & Welch, R. A. (1981). Dexamethasone concentrations in plasma and milk of cows following the injection of long- and short-acting dexamethasone esters. Australian Journal of Biological Sciences, 34(3), 313-319.
Ferranti, C., Famele, M., Palleschi, L., Bozzetta, E., Pezzolato, M., & Draisci, R. (2013). Excretion profile of corticosteroids in bovine urine compared with tissue residues after therapeutic and growth-promoting administration of dexamethasone. Steroids, 78(9), 803-812.
Girolami, F., Donalisio, C., Tagliante, M., Gatto, S., Bertarelli, D., Balbo, A., & Nebbia, C. (2010). Illicit use of dexamethasone in meat cattle: Rationale, effects on treated animals, and traditional and innovative diagnostic techniques. Large Animal Review, 16, 113-124.
Graham, S. F., Ruiz-Aracama, A., Lommen, A., Cannizzo, F. T., Biolatti, B., Elliott, C. T., & Mooney, M. H. (2012). Use of NMR metabolomic plasma profiling methodologies to identify illicit growth-promoting administrations. Analytical and Bioanalytical Chemistry, 403(2), 573-582.
Joint FAO/WHO Expert Committee on Food Additives. (2006). Software-based workbook for statistical evaluation of residue depletion data for veterinary drugs. https://www.fao.org/food/food-safety-quality/scientific-advice/jecfa/guidelines0/residue-depletion/en/
Odore, R., Badino, P., Barbero, R., Cuniberti, B., Pagliasso, S., Girardi, C., & Re, G. (2007). Regulation of tissue beta-adrenergic, glucocorticoid and androgen receptors induced by repeated exposure to growth promoters in male veal calves. Research in Veterinary Science, 83(2), 227-233.
Tatone, E. H., Duffield, T. F., Capel, M. B., DeVries, T. J., LeBlanc, S. J., & Gordon, J. L. (2016). A randomized controlled trial of dexamethasone as an adjunctive therapy to propylene glycol for treatment of hyperketonemia in postpartum dairy cattle. Journal of Dairy Science, 99(11), 8991-9000.
The European Agency for the Evaluation of Medicinal Products. (1997). Dexamethasone Summary Report (1). https://www.ema.europa.eu/en/documents/mrl-report/dexamethasone-summary-report-1-committee-veterinary-medicinal-products_en.pdf
The European Commission. (2010). Commission Regulation (EU) No. 37/2010 on pharmacologically active substances and their classification regarding maximum residue limits in foodstuffs of animal origin. Official Journal of the European Union, L 15 (20 January 2010), 1-72.
The Pew Charitable Trusts. (2016). The National Residue Program for Meat, Poultry, and Egg Products. Philadephia, PA. https://www.pewtrusts.org/en/research-and-analysis/reports/2016/03/the-national-residue-program-for-meat-poultry-and-egg-products
Van Den Hauwe, O., Schneider, M., Sahin, A., Van Peteghem, C. H., & Naegeli, H. (2003). Immunochemical screening and liquid chromatographic-tandem mass spectrometric confirmation of drug residues in edible tissues of calves injected with a therapeutic dose of the synthetic glucocorticoids dexamethasone and flumethasone. Journal of Agricultural and Food Chemistry, 51(1), 326-330.
VICH. (2015). VICH GL 48 Studies to evaluate the metabolism and residue kinetics of veterinary drugs in food-producing animals. Brussels. https://www.vichsec.org/en/home.html