Exploring the Impact of Organic Solvent Quality and Unusual Adduct Formation during LC-MS-Based Lipidomic Profiling.
MS/MS annotation
adduct formation
lipidomics
lipids
liquid chromatography
mass spectrometry
metabolomics
method development
misidentification
solvent quality
Journal
Metabolites
ISSN: 2218-1989
Titre abrégé: Metabolites
Pays: Switzerland
ID NLM: 101578790
Informations de publication
Date de publication:
22 Aug 2023
22 Aug 2023
Historique:
received:
03
08
2023
revised:
19
08
2023
accepted:
21
08
2023
medline:
27
9
2023
pubmed:
27
9
2023
entrez:
27
9
2023
Statut:
epublish
Résumé
Liquid chromatography-mass spectrometry (LC-MS) is the key technique for analyzing complex lipids in biological samples. Various LC-MS modes are used for lipid separation, including different stationary phases, mobile-phase solvents, and modifiers. Quality control in lipidomics analysis is crucial to ensuring the generated data's reliability, reproducibility, and accuracy. While several quality control measures are commonly discussed, the impact of organic solvent quality during LC-MS analysis is often overlooked. Additionally, the annotation of complex lipids remains prone to biases, leading to potential misidentifications and incomplete characterization of lipid species. In this study, we investigate how LC-MS-grade isopropanol from different vendors may influence the quality of the mobile phase used in LC-MS-based untargeted lipidomic profiling of biological samples. Furthermore, we report the occurrence of an unusual, yet highly abundant, ethylamine adduct [M+46.0651]
Identifiants
pubmed: 37755246
pii: metabo13090966
doi: 10.3390/metabo13090966
pmc: PMC10536874
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Ministry of Health
ID : NU20-01-00186
Organisme : Ministry of Health
ID : NU22-02-00161
Organisme : Czech Science Foundation
ID : 21-00477S
Organisme : Ministry of Education Youth and Sports
ID : LTAUSA19124
Organisme : Ministry of Education Youth and Sports
ID : LX22NPO5104
Organisme : Czech Academy of Sciences
ID : LQ200111901
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