Clinical Significance of Erythroferrone and Bone Morphogenetic Protein-6 in Patients with Anemia in the Course of Inflammatory Bowel Disease.
anemia
bone morphogenetic protein
erythroferrone
ferritin
inflammatory bowel disease
Journal
Metabolites
ISSN: 2218-1989
Titre abrégé: Metabolites
Pays: Switzerland
ID NLM: 101578790
Informations de publication
Date de publication:
12 Sep 2023
12 Sep 2023
Historique:
received:
26
06
2023
revised:
04
09
2023
accepted:
08
09
2023
medline:
27
9
2023
pubmed:
27
9
2023
entrez:
27
9
2023
Statut:
epublish
Résumé
In recent years, a steady increase in the incidence of inflammatory bowel diseases (IBD) has been observed with anemia as their most common extraintestinal symptom. Erythroferrone and Bone Morphogenetic Protein 6 (BMP-6) are recently identified cytokines involved in the process of increased erythropoiesis in anemia of various pathomechanisms. The aim of this study was to analyze the concentration of erythroferrone and BMP-6 in IBD patients in relation to clinical and laboratory data. The study comprised 148 patients: 118 with IBD, including 73 (61.85%) diagnosed with anemia (42 with Crohn's disease (CD) (66.7%) and 31 (56.4%) with ulcerative colitis (UC)) and 30 as a control group. The erythroferrone concentration was significantly higher in IBD patients with anemia (
Identifiants
pubmed: 37755286
pii: metabo13091006
doi: 10.3390/metabo13091006
pmc: PMC10537870
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Medical University of Lodz
ID : 503/1-002-01/503-11-001-19-00
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