Distinctive calcium isotopic composition of mice organs and fluids: implications for biological research.
Body compartments
Calcium isotopes
Genetic background
Isotope fractionation
Sex
Journal
Analytical and bioanalytical chemistry
ISSN: 1618-2650
Titre abrégé: Anal Bioanal Chem
Pays: Germany
ID NLM: 101134327
Informations de publication
Date de publication:
Nov 2023
Nov 2023
Historique:
received:
15
03
2023
accepted:
12
09
2023
revised:
07
09
2023
pubmed:
27
9
2023
medline:
27
9
2023
entrez:
27
9
2023
Statut:
ppublish
Résumé
The stable calcium (Ca) isotopes offer a minimally invasive method for assessing Ca balance in the body, providing a new avenue for research and clinical applications. In this study, we measured the Ca isotopic composition of soft tissues (brain, muscle, liver, and kidney), mineralized tissue (bone), and blood (plasma) from 10 mice (5 females and 5 males) with three different genetic backgrounds and same age (3 months old). The results reveal a distinctive Ca isotopic composition in different body compartments of mice, primally controlled by each compartment's unique Ca metabolism and genetic background, independent of sex. The bones are enriched in the lighter Ca isotopes (δ
Identifiants
pubmed: 37755490
doi: 10.1007/s00216-023-04962-7
pii: 10.1007/s00216-023-04962-7
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
6839-6850Subventions
Organisme : European Research Council (ERC) for the Proof of Concept Grant
ID : 101059236
Informations de copyright
© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH, DE part of Springer Nature.
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