Divergent roles for STAT4 in shaping differentiation of cytotoxic ILC1 and NK cells during gut inflammation.
JAK/STAT
NK cells
inflammation
innate lymphocytes
transcriptional regulations
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
03 10 2023
03 10 2023
Historique:
pmc-release:
27
03
2024
medline:
29
9
2023
pubmed:
27
9
2023
entrez:
27
9
2023
Statut:
ppublish
Résumé
Natural killer (NK) cells and type 1 innate lymphoid cells (ILC1) require signal transducer and activator of transcription 4 (STAT4) to elicit rapid effector responses and protect against pathogens. By combining genetic and transcriptomic approaches, we uncovered divergent roles for STAT4 in regulating effector differentiation of these functionally related cell types.
Identifiants
pubmed: 37756335
doi: 10.1073/pnas.2306761120
pmc: PMC10556635
doi:
Substances chimiques
STAT5 Transcription Factor
0
Antineoplastic Agents
0
STAT4 protein, human
0
STAT4 Transcription Factor
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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