Partial Radiation Nephrectomy Using 90 Y Resin Microspheres: A Treatment Option for Renal Tumors With Malignant Characteristics in Patients Not Candidates for Surgery.


Journal

Clinical nuclear medicine
ISSN: 1536-0229
Titre abrégé: Clin Nucl Med
Pays: United States
ID NLM: 7611109

Informations de publication

Date de publication:
01 11 2023
Historique:
medline: 24 11 2023
pubmed: 27 9 2023
entrez: 27 9 2023
Statut: ppublish

Résumé

Contrast-enhancing renal masses are likely to be malignant in over 90% of cases due to the high diagnostic accuracy of abdominal imaging. In this situation, tumor biopsy is unnecessary and should be managed as a renal cell carcinoma. Resection remains the only potentially curative treatment. However, as in the case herein presented, comorbidities can prevent surgical resection. Radioembolization with 90 Y microspheres is an intra-arterial procedure capable of delivering high doses of radiation to tumors. The present case demonstrates the concept of partial radiation nephrectomy in treating renal tumors with malignant characteristics in patients not amenable to surgery.

Identifiants

pubmed: 37756468
doi: 10.1097/RLU.0000000000004792
pii: 00003072-202311000-00010
doi:

Types de publication

Case Reports Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

960-962

Informations de copyright

Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.

Déclaration de conflit d'intérêts

Conflicts of interest and sources of funding: none declared. The authors receive consultancy fees from Sirtex Medical and speaker fees from Sirtex Medical.

Références

Campbell S, Uzzo RG, Allaf ME, et al. Renal mass and localized renal cancer: AUA guideline. J Urol . 2017;198:520–529.
Frank I, Blute ML, Cheville JC, et al. Solid renal tumors: an analysis of pathological features related to tumor size. J Urol . 2003;170:2217–2220.
Kutikov A, Smaldone MC, Uzzo RG, et al. Renal mass biopsy: always, sometimes, or never? Eur Urol . 2016;70:403–406.
Hamoui N, Gates VL, Gonzalez J, et al. Radioembolization of renal cell carcinoma using yttrium-90 microspheres. J Vasc Interv Radiol . 2013;24:298–300.
de Souza PL, Aslan P, Clark W, et al. RESIRT: a phase 1 study of selective internal radiation therapy using yttrium-90 resin microspheres in patients with primary renal cell carcinoma. Clin Genitourin Cancer . 2022;20:442–451.
de Silva S, Mackie S, Aslan P, et al. Histological comparison of kidney tissue following radioembolization with yttrium-90 resin microspheres and embolization with bland microspheres. Cardiovasc Intervent Radiol . 2016;39:1743–1749.
Bilbao JI, de Martino A, de Luis E, et al. Biocompatibility, inflammatory response, and recannalization characteristics of nonradioactive resin microspheres: histological findings. Cardiovasc Intervent Radiol . 2009;32:727–736.
MacKie S, de Silva S, Aslan P, et al. Super selective radio embolization of the porcine kidney with 90 Yttrium resin microspheres: a feasibility, safety and dose ranging study. J Urol . 2011;185:285–290.

Auteurs

Antonio Martínez de la Cuesta (AM)

Department of Radiology.

Fernando Rotellar (F)

HPB and Liver Transplant Unit, Department of General Surgery, Clínica Universidad de Navarra, Universidad de Navarra, Pamplona, Spain.

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