A human genome editing-based MLL::AF4 ALL model recapitulates key cellular and molecular leukemogenic features.
Journal
Blood
ISSN: 1528-0020
Titre abrégé: Blood
Pays: United States
ID NLM: 7603509
Informations de publication
Date de publication:
16 Nov 2023
16 Nov 2023
Historique:
accepted:
18
08
2023
received:
18
04
2023
pubmed:
27
9
2023
medline:
27
9
2023
entrez:
27
9
2023
Statut:
ppublish
Résumé
Cellular ontogeny and MLL breakpoint site influence the capacity of MLL-edited CD34+ hematopoietic cells to initiate and recapitulate infant patients' features in pro-B-cell acute lymphoblastic leukemia (B-ALL). We provide key insights into the leukemogenic determinants of MLL-AF4+ infant B-ALL.
Identifiants
pubmed: 37756522
pii: 498120
doi: 10.1182/blood.2023020858
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1752-1756Informations de copyright
© 2023 by The American Society of Hematology.