The effect of melatonin on sleep quality and cognitive function of individuals undergoing hemodialysis.

Cognitive status Hemodialysis Melatonin Pittsburgh Sleep quality

Journal

Sleep medicine
ISSN: 1878-5506
Titre abrégé: Sleep Med
Pays: Netherlands
ID NLM: 100898759

Informations de publication

Date de publication:
Nov 2023
Historique:
received: 15 12 2022
revised: 26 08 2023
accepted: 12 09 2023
pubmed: 27 9 2023
medline: 27 9 2023
entrez: 27 9 2023
Statut: ppublish

Résumé

and purpose: This study aimed to investigate the effect of melatonin on sleep quality and cognitive function of individuals undergoing hemodialysis. In this randomized controlled clinical trial, 102 eligible individuals were assigned to two equal intervention and control groups. The intervention group received melatonin 3 mg tablets half an hour before going to bed for six weeks, while the control group was given a placebo with similar conditions. This study had 102 participants who were divided into intervention and control groups. The mean age of the participants was 58.30 (SD = 12.10). Among the participants, 54.90% were female. Moreover, 33.33% of the individuals received dialysis for four years or longer. After the intervention, the mean and standard deviation of the Pittsburgh Sleep Quality Index (PSQI) was 12.66 (SD = 3.09) in the intervention group and 18.86 (SD = 3.8) in the control group (P < 0.001). Moreover, the mean sleep quality index in the intervention group showed a statistically significant difference before and after the intervention (P < 0.001); the PSQI score declined from 20.21 to 12.66. Likewise, there was a statistically significant difference between the two groups after intervention in the mean Montreal Cognitive Assessment (MoCA) index (P = 0.002); it was 24.27 (SD = 3.42) in the intervention group and 22.15 (SD = 2.3) in the control group. The mean MoCA score in the intervention group showed a significant difference before and after the intervention (P < 0.001), increasing from 21.19 to 24.27. According to the study's findings, melatonin can improve individuals undergoing hemodialysis' cognitive function and sleep quality.

Sections du résumé

BACKGROUND BACKGROUND
and purpose: This study aimed to investigate the effect of melatonin on sleep quality and cognitive function of individuals undergoing hemodialysis.
MATERIALS AND METHODS METHODS
In this randomized controlled clinical trial, 102 eligible individuals were assigned to two equal intervention and control groups. The intervention group received melatonin 3 mg tablets half an hour before going to bed for six weeks, while the control group was given a placebo with similar conditions.
RESULTS RESULTS
This study had 102 participants who were divided into intervention and control groups. The mean age of the participants was 58.30 (SD = 12.10). Among the participants, 54.90% were female. Moreover, 33.33% of the individuals received dialysis for four years or longer. After the intervention, the mean and standard deviation of the Pittsburgh Sleep Quality Index (PSQI) was 12.66 (SD = 3.09) in the intervention group and 18.86 (SD = 3.8) in the control group (P < 0.001). Moreover, the mean sleep quality index in the intervention group showed a statistically significant difference before and after the intervention (P < 0.001); the PSQI score declined from 20.21 to 12.66. Likewise, there was a statistically significant difference between the two groups after intervention in the mean Montreal Cognitive Assessment (MoCA) index (P = 0.002); it was 24.27 (SD = 3.42) in the intervention group and 22.15 (SD = 2.3) in the control group. The mean MoCA score in the intervention group showed a significant difference before and after the intervention (P < 0.001), increasing from 21.19 to 24.27.
CONCLUSION CONCLUSIONS
According to the study's findings, melatonin can improve individuals undergoing hemodialysis' cognitive function and sleep quality.

Identifiants

DOI: 10.1016/j.sleep.2023.09.011 PMID: 37757507
pubmed: 37757507
pii: S1389-9457(23)00334-9
doi: 10.1016/j.sleep.2023.09.011
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

105-110

Informations de copyright

Copyright © 2023 Elsevier B.V. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest We certify that there is no conflict of interest for each author.

Auteurs

Salehi Hikooei Marzieh (SH)

Critical Care Nursing, Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran. Electronic address: marziesalehi12@gmail.com.

Hedayat Jafari (H)

Medical-Surgical Nursing Department, Traditional and Complementary Medicine Research Center, Addiction Institute, Mazandaran University of Medical Sciences, Sari, Iran.

Seyed Afshin Shorofi (SA)

Medical-Surgical Nursing Department, Traditional and Complementary Medicine Research Center, Addiction Institute, Mazandaran University of Medical Sciences, Sari, Iran; Flinders University, Adelaide, Australia.

Javad Setareh (J)

Psychiatry and Behavioral Sciences Research Center, Addiction Institute, Mazandaran University of Medical Sciences, Sari, Iran.

Mahmood Moosazadeh (M)

Gastrointestinal Cancer Research Center, Non-communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran.

Fatemeh Espahbodi (F)

Internal Medicine Department, School of Medicine, Diabetes Research Center, Mazandaran University of Medical Sciences, Sari, Iran.

Majid Saeedi (M)

School of Pharmacy, Pharmaceutical Sciences Research Center, Hemoglobinopathy Institute, Mazandaran University of Medical Sciences, Sari, Iran.

Paul Arbon (P)

Torrens Resilience Institute, Flinders University, Adelaide, Australia.

Pooyan Ghorbani Vajargah (P)

Department of Medical-Surgical Nursing, School of Nursing and Midwifery, Guilan University of Medical Sciences, Rasht, Iran; Burn and Regenerative Medicine Research Center, Guilan University of Medical Sciences, Rasht, Iran.

Samad Karkhah (S)

Department of Medical-Surgical Nursing, School of Nursing and Midwifery, Guilan University of Medical Sciences, Rasht, Iran; Burn and Regenerative Medicine Research Center, Guilan University of Medical Sciences, Rasht, Iran.

Classifications MeSH