Re-evaluating the mosquito RNAi pathway's influence on arbovirus transmission.

Aedes aegypti RNA interference (RNAi) arbovirus innate immunity mosquito transmission bottleneck

Journal

Trends in parasitology
ISSN: 1471-5007
Titre abrégé: Trends Parasitol
Pays: England
ID NLM: 100966034

Informations de publication

Date de publication:
Nov 2023
Historique:
received: 10 09 2023
accepted: 11 09 2023
pubmed: 28 9 2023
medline: 28 9 2023
entrez: 27 9 2023
Statut: ppublish

Résumé

With new RNA interference (RNAi) pathway-deficient mosquitoes, Merkling et al. invite a shift in our view of this pathway's role in regulating arthropod-borne virus (arbovirus) transmission. While loss of RNAi function enhanced early viral replication, little impact on transmission was observed, inviting renewed exploration of molecular barriers to arbovirus transmission.

Identifiants

pubmed: 37758630
pii: S1471-4922(23)00226-X
doi: 10.1016/j.pt.2023.09.005
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

898-899

Informations de copyright

Copyright © 2023 The Author. Published by Elsevier Ltd.. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests The author declares no competing interests.

Auteurs

Kevin Maringer (K)

The Pirbright Institute, Ash Road, Pirbright, Surrey GU24 0NF, UK. Electronic address: kevin.maringer@pirbright.ac.uk.

Classifications MeSH