A novel aromatic compound from the fungus Synnemellisia sp. FKR-0921.

Hypocreales / chemistry Magnetic Resonance Spectroscopy Molecular Structure Spectroscopy, Fourier Transform Infrared Phenols / chemistry beta-Lactamase Inhibitors / chemistry Anti-Infective Agents / chemistry

Journal

The Journal of antibiotics
ISSN: 1881-1469
Titre abrégé: J Antibiot (Tokyo)
Pays: England
ID NLM: 0151115

Informations de publication

Date de publication:
Dec 2023
Historique:
received: 14 05 2023
accepted: 11 09 2023
revised: 15 08 2023
medline: 28 11 2023
pubmed: 28 9 2023
entrez: 27 9 2023
Statut: ppublish

Résumé

The filamentous fungus Synnemellisia sp. strain FKR-0921 was obtained from soil collected on Kume Island, Okinawa. The MeOH extract of FKR-0921 cultured on a solid rice medium yielded a new aromatic compound, synnemellisitriol A (1). The structure, including the absolute configuration, was elucidated by spectroscopic analysis (FT-IR, NMR, and HR-ESI-MS), and the absolute configuration at C-9 of 1 was determined using the modified Mosher's method. Additionally, 1 was evaluated for its biological activities, including metallo-β-lactamase inhibitory activity, type III secretion system inhibitory activity, antimicrobial activity, antimalarial activity, and cytotoxicity.

Identifiants

DOI: 10.1038/s41429-023-00657-4 PMID: 37758818
pubmed: 37758818
doi: 10.1038/s41429-023-00657-4
pii: 10.1038/s41429-023-00657-4
doi:

Substances chimiques

Phenols 0
beta-Lactamase Inhibitors 0
Anti-Infective Agents 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

706-710

Informations de copyright

© 2023. The Author(s), under exclusive licence to the Japan Antibiotics Research Association.

Références

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Auteurs

Arisu Tahara (A)

Department of Biosciences and Biotechnology, Faculty of Agriculture, University of the Ryukyus, 1 Senbaru, Nishihara, Okinawa, 903-0213, Japan.

Kazuki Tani (K)

Department of Biosciences and Biotechnology, Faculty of Agriculture, University of the Ryukyus, 1 Senbaru, Nishihara, Okinawa, 903-0213, Japan.

Miyu Wakatsuki (M)

Department of Biosciences and Biotechnology, Faculty of Agriculture, University of the Ryukyus, 1 Senbaru, Nishihara, Okinawa, 903-0213, Japan.

Toshiyuki Tokiwa (T)

Ōmura Satoshi Memorial Institute, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan.

Mayuka Higo (M)

Ōmura Satoshi Memorial Institute, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan.

Kenichi Nonaka (K)

Ōmura Satoshi Memorial Institute, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan.

Tomoyasu Hirose (T)

Ōmura Satoshi Memorial Institute, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan.
ORCID: 0000-0002-9463-8181

Rei Hokari (R)

Ōmura Satoshi Memorial Institute, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan.

Aki Ishiyama (A)

Ōmura Satoshi Memorial Institute, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan.
ORCID: 0000-0003-4703-8834

Masato Iwatsuki (M)

Ōmura Satoshi Memorial Institute, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan.
ORCID: 0000-0001-8373-4314

Yoshihiro Watanabe (Y)

Ōmura Satoshi Memorial Institute, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan.
ORCID: 0000-0002-5756-0530

Masako Honsho (M)

Ōmura Satoshi Memorial Institute, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan.

Yukihiro Asami (Y)

Ōmura Satoshi Memorial Institute, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan.
ORCID: 0000-0003-1821-9169

Hidehito Matsui (H)

Ōmura Satoshi Memorial Institute, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan.
ORCID: 0000-0003-0099-3340

Toshiaki Sunazuka (T)

Ōmura Satoshi Memorial Institute, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan.

Hideaki Hanaki (H)

Ōmura Satoshi Memorial Institute, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan.

Toshiaki Teruya (T)

Faculty of Education, University of the Ryukyus, 1 Senbaru, Nishihara, Okinawa, 903-0213, Japan.
ORCID: 0000-0002-7018-7734

Takahiro Ishii (T)

Department of Biosciences and Biotechnology, Faculty of Agriculture, University of the Ryukyus, 1 Senbaru, Nishihara, Okinawa, 903-0213, Japan. ishiit@agr.u-ryukyu.ac.jp.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Champignons › Ascomycota › Hypocreales › A novel aromatic compound from the fungus...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Analyse spectrale › Spectroscopie par résonance magnétique › A novel aromatic compound from the fungus...
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › A novel aromatic compound from the fungus...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Analyse spectrale › Spectrophotométrie › Spectrophotométrie IR › Spectroscopie infrarouge à transformée de Fourier › A novel aromatic compound from the fungus...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Phénols › A novel aromatic compound from the fungus...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antibactériens › Inhibiteurs des bêta-lactamases › A novel aromatic compound from the fungus...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › A novel aromatic compound from the fungus...