Recent Advances in SARS-CoV-2 Main Protease Inhibitors: From Nirmatrelvir to Future Perspectives.

COVID-19 Paxlovid SARS-CoV-2 Mpro coronavirus nirmatrelvir peptidomimetics protease inhibitors

Journal

Biomolecules
ISSN: 2218-273X
Titre abrégé: Biomolecules
Pays: Switzerland
ID NLM: 101596414

Informations de publication

Date de publication:
02 Sep 2023
Historique:
received: 29 07 2023
revised: 28 08 2023
accepted: 31 08 2023
medline: 28 9 2023
pubmed: 28 9 2023
entrez: 28 9 2023
Statut: epublish

Résumé

The main protease (M

Identifiants

pubmed: 37759739
pii: biom13091339
doi: 10.3390/biom13091339
pmc: PMC10647625
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : University of Messina
ID : FFABR_PA_MICALE_NICOLA_ATENEO_2022

Références

Sci Bull (Beijing). 2021 Apr 15;66(7):661-663
pubmed: 33163253
Org Biomol Chem. 2022 Nov 02;20(42):8293-8304
pubmed: 36227250
BMJ. 2021 Nov 8;375:n2713
pubmed: 34750163
Science. 2020 Jun 19;368(6497):1331-1335
pubmed: 32321856
Future Med Chem. 2022 Mar;14(6):393-405
pubmed: 35220726
FEBS J. 2014 Sep;281(18):4085-96
pubmed: 25039866
J Med Chem. 2022 Feb 24;65(4):2880-2904
pubmed: 34347470
J Med Chem. 2022 Jul 14;65(13):9376-9395
pubmed: 35709506
Eur J Med Chem. 2022 Mar 5;231:114130
pubmed: 35114541
ACS Cent Sci. 2022 Apr 27;8(4):405-407
pubmed: 35505871
Signal Transduct Target Ther. 2023 Mar 16;8(1):128
pubmed: 36928316
Org Lett. 2019 Oct 18;21(20):8261-8265
pubmed: 31599599
Sci Rep. 2022 Feb 15;12(1):2505
pubmed: 35169179
Bioorg Med Chem. 2023 May 3;87:117316
pubmed: 37187077
Science. 2021 Mar 26;371(6536):1374-1378
pubmed: 33602867
Nat Commun. 2021 Jun 15;12(1):3623
pubmed: 34131140
Eur J Med Chem. 2022 Feb 5;229:114046
pubmed: 34995923
Acta Pharm Sin B. 2022 Feb;12(2):581-599
pubmed: 34485029
Int J Mol Sci. 2021 Jun 30;22(13):
pubmed: 34208928
J Med Chem. 2023 Feb 23;66(4):2663-2680
pubmed: 36757959
J Med Chem. 2020 Nov 12;63(21):12725-12747
pubmed: 33054210
J Virol. 2022 Jan 12;96(1):e0125321
pubmed: 34586857
Nat Chem Biol. 2019 Mar;15(3):250-258
pubmed: 30643284
Eur J Med Chem. 2021 Oct 15;222:113584
pubmed: 34118724
Viruses. 2022 Sep 18;14(9):
pubmed: 36146880
ACS Pharmacol Transl Sci. 2021 Mar 11;4(3):1096-1110
pubmed: 35287429
Curr Opin Chem Biol. 2008 Jun;12(3):292-6
pubmed: 18423417
Biochemistry. 1991 May 14;30(19):4678-87
pubmed: 2029515
Nat Rev Drug Discov. 2023 Jul;22(7):585-603
pubmed: 37173515
Int J Mol Sci. 2021 Oct 29;22(21):
pubmed: 34769210
Bioorg Med Chem Lett. 2022 Feb 15;58:128526
pubmed: 34998903
J Med Chem. 2023 Sep 14;66(17):12266-12283
pubmed: 37594952
Eur J Med Chem. 2022 Jan 15;228:114030
pubmed: 34883292
Eur J Med Chem. 2023 Feb 5;247:115021
pubmed: 36549112
Bioorg Med Chem Lett. 2021 Jul 1;43:128099
pubmed: 33984473
ACS Infect Dis. 2021 Mar 12;7(3):586-597
pubmed: 33645977
J Med Chem. 2021 Jul 22;64(14):10047-10058
pubmed: 34213885
Expert Opin Ther Pat. 2021 Apr;31(4):309-324
pubmed: 33246378
Org Biomol Chem. 2023 May 10;21(18):3811-3824
pubmed: 37078164
Eur J Med Chem. 2023 Nov 5;259:115667
pubmed: 37482021
RSC Med Chem. 2023 Aug 17;14(10):2068-2078
pubmed: 37859715
Cell Chem Biol. 2021 Dec 16;28(12):1795-1806.e5
pubmed: 34174194
ACS Pharmacol Transl Sci. 2021 Jun 09;4(4):1408-1421
pubmed: 34414360
Bioorg Med Chem. 2008 Apr 15;16(8):4652-60
pubmed: 18329272
Protein J. 2020 Apr;39(2):97-105
pubmed: 32072438
MedComm (2020). 2022 Jul 14;3(3):e151
pubmed: 35845352
J Chem Inf Model. 2021 Aug 23;61(8):3917-3926
pubmed: 34279924
J Med Chem. 2023 Aug 24;66(16):11040-11055
pubmed: 37561993
Med Chem Res. 2022;31(2):244-273
pubmed: 35039740
J Chem Inf Model. 2021 Apr 26;61(4):2062-2073
pubmed: 33784094
Nat Commun. 2021 May 24;12(1):3061
pubmed: 34031399
Chembiochem. 2023 Jun 1;24(11):e202300116
pubmed: 37069799
Int J Mol Sci. 2022 Oct 15;23(20):
pubmed: 36293216
Chem Sci. 2022 Feb 15;13(10):3027-3034
pubmed: 35432850
J Med Chem. 2022 Feb 24;65(4):2848-2865
pubmed: 33891389
Science. 2003 Jun 13;300(5626):1763-7
pubmed: 12746549
J Chem Inf Model. 2022 Jan 10;62(1):116-128
pubmed: 34793155
ACS Med Chem Lett. 2021 Sep 29;13(1):140-147
pubmed: 35043075
Molecules. 2023 Jan 04;28(2):
pubmed: 36677572
J Med Chem. 2022 Dec 22;65(24):16902-16917
pubmed: 36475694
Mar Drugs. 2022 Feb 24;20(3):
pubmed: 35323462
Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13190-5
pubmed: 14585926
Bioorg Chem. 2021 Jul;112:104889
pubmed: 33915460
J Med Chem. 2020 May 14;63(9):4562-4578
pubmed: 32045235
J Med Chem. 2022 Oct 13;65(19):13343-13364
pubmed: 36107752
Science. 2021 Dec 24;374(6575):1586-1593
pubmed: 34726479
J Mol Cell Biol. 2022 Sep 21;14(6):
pubmed: 35759391
J Struct Biol. 2020 Sep 1;211(3):107575
pubmed: 32653646
Eur J Med Chem. 2023 Sep 5;257:115512
pubmed: 37253309
Science. 2020 Apr 24;368(6489):409-412
pubmed: 32198291
ACS Pharmacol Transl Sci. 2020 Sep 04;3(5):1008-1016
pubmed: 33062953
Biomolecules. 2021 Apr 19;11(4):
pubmed: 33921886
Eur J Med Chem. 2022 Oct 5;240:114596
pubmed: 35839690
ChemMedChem. 2022 Jan 5;17(1):e202100576
pubmed: 34651447
J Med Chem. 2022 Feb 24;65(4):2905-2925
pubmed: 34242027
Antiviral Res. 2022 Sep;205:105381
pubmed: 35835291
Eur J Med Chem. 2020 Nov 15;206:112711
pubmed: 32810751
Chem Sci. 2022 Feb 10;13(13):3674-3687
pubmed: 35432906
J Am Chem Soc. 2022 Nov 23;144(46):21035-21045
pubmed: 36356199
Eur J Med Chem. 2023 Sep 5;257:115487
pubmed: 37257212
J Med Chem. 2022 Oct 13;65(19):12500-12534
pubmed: 36169610
Nat Commun. 2022 Apr 27;13(1):2268
pubmed: 35477935
Nat Commun. 2021 Apr 1;12(1):2016
pubmed: 33795671
Nat Commun. 2022 Apr 7;13(1):1891
pubmed: 35393402
Nat Commun. 2021 Jan 28;12(1):668
pubmed: 33510133
J Med Chem. 2021 Oct 14;64(19):14702-14714
pubmed: 34528437
Nature. 2020 Jun;582(7811):289-293
pubmed: 32272481
Molecules. 2020 Sep 03;25(17):
pubmed: 32899354
J Am Chem Soc. 2021 Dec 15;143(49):20697-20709
pubmed: 34860011
ACS Comb Sci. 2020 Jun 8;22(6):297-305
pubmed: 32402186
J Med Chem. 2022 Feb 24;65(4):2794-2808
pubmed: 33872498
J Biol Chem. 2022 Jun;298(6):101972
pubmed: 35461811
Nat Commun. 2023 Feb 25;14(1):1076
pubmed: 36841831
Int J Mol Sci. 2020 Apr 28;21(9):
pubmed: 32353978
Science. 2021 May 7;372(6542):642-646
pubmed: 33811162
J Med Chem. 2023 Sep 14;66(17):12237-12248
pubmed: 37595260
Sci Adv. 2020 Dec 9;6(50):
pubmed: 33158912
J Med Chem. 2022 Oct 13;65(19):13328-13342
pubmed: 36179320
Angew Chem Int Ed Engl. 2021 Apr 26;60(18):10423-10429
pubmed: 33655614
Chem Rev. 2016 Mar 9;116(5):3241-305
pubmed: 26881454
J Med Chem. 2016 Jul 28;59(14):6595-628
pubmed: 26878082
Nat Commun. 2020 Aug 27;11(1):4282
pubmed: 32855413
mBio. 2020 Aug 20;11(4):
pubmed: 32820005
Nat Microbiol. 2022 May;7(5):716-725
pubmed: 35477751
J Med Chem. 2022 Feb 24;65(4):2866-2879
pubmed: 34570513
ACS Infect Dis. 2021 Jun 11;7(6):1457-1468
pubmed: 33570381
Eur J Med Chem. 2013 Oct;68:372-84
pubmed: 23994330
ChemMedChem. 2021 Mar 18;16(6):942-948
pubmed: 33283984
J Biol Chem. 2020 Dec 11;295(50):17365-17373
pubmed: 33060199
J Am Chem Soc. 2022 Feb 23;144(7):2905-2920
pubmed: 35142215
Int J Mol Sci. 2021 Jan 30;22(3):
pubmed: 33573283
RSC Med Chem. 2021 Aug 20;12(10):1722-1730
pubmed: 34778773
Eur J Med Chem. 2022 Oct 5;240:114570
pubmed: 35779291
J Med Chem. 2022 May 12;65(9):6499-6512
pubmed: 35352927
Eur J Med Chem. 2013 Jan;59:1-6
pubmed: 23202846

Auteurs

Andrea Citarella (A)

Department of Chemistry, University of Milan, Via Golgi 19, 20133 Milano, Italy.

Alessandro Dimasi (A)

Department of Chemistry, University of Milan, Via Golgi 19, 20133 Milano, Italy.

Davide Moi (D)

Department of Chemical and Geological Sciences, University of Cagliari, S.P. 8 CA, 09042 Cagliari, Italy.

Daniele Passarella (D)

Department of Chemistry, University of Milan, Via Golgi 19, 20133 Milano, Italy.

Angela Scala (A)

Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno D'Alcontres 31, 98166 Messina, Italy.

Anna Piperno (A)

Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno D'Alcontres 31, 98166 Messina, Italy.

Nicola Micale (N)

Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno D'Alcontres 31, 98166 Messina, Italy.

Classifications MeSH