Glymphatic-System Function Is Associated with Addiction and Relapse in Heroin Dependents Undergoing Methadone Maintenance Treatment.

DTI-ALPS glymphatic system heroin dependence methadone maintenance treatment (MMT)

Journal

Brain sciences
ISSN: 2076-3425
Titre abrégé: Brain Sci
Pays: Switzerland
ID NLM: 101598646

Informations de publication

Date de publication:
07 Sep 2023
Historique:
received: 29 06 2023
revised: 29 08 2023
accepted: 04 09 2023
medline: 28 9 2023
pubmed: 28 9 2023
entrez: 28 9 2023
Statut: epublish

Résumé

This study investigates the impact of methadone maintenance treatment (MMT) on the brain glymphatic system (GS) in opioid addiction in China. A total of 51 male MMT patients, 48 demographically matched healthy controls (HCs), and 20 heroin dependents (HDs) were recruited for this study. The GS functioning was assessed using diffusion-tensor-imaging analysis along perivascular spaces (DTI-ALPS index) and the bilateral ALPS divergency (DivALPS). Group differences were analyzed utilizing ANOVA and two-sample

Identifiants

pubmed: 37759893
pii: brainsci13091292
doi: 10.3390/brainsci13091292
pmc: PMC10526898
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : National Natural Science Foundation of China
ID : 82071497;81771813

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Auteurs

Lei Wang (L)

Department of Radiology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China.
Department of Radiology, Xi'an Daxing Hospital, Xi'an 710016, China.

Yue Qin (Y)

Department of Radiology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China.
Department of Radiology, Xi'an Daxing Hospital, Xi'an 710016, China.

Xiaoshi Li (X)

Department of Radiology, Xi'an Daxing Hospital, Xi'an 710016, China.

Xin Li (X)

Department of Radiology, Xi'an Daxing Hospital, Xi'an 710016, China.

Yuwei Liu (Y)

Department of Medical Imaging, People's Hospital of Tongchuan City, Tongchuan 727000, China.

Wei Li (W)

Department of Radiology, Tangdu Hospital, Air Force Military Medical University, Xi'an 710038, China.

Yarong Wang (Y)

Department of Radiology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China.

Classifications MeSH