Neuroimmune Support of Neuronal Regeneration and Neuroplasticity following Cerebral Ischemia in Juvenile Mice.
cerebral ischemia
functional recovery
neural regeneration
neurogenesis
neuroimmune signaling
synaptic plasticity
Journal
Brain sciences
ISSN: 2076-3425
Titre abrégé: Brain Sci
Pays: Switzerland
ID NLM: 101598646
Informations de publication
Date de publication:
17 Sep 2023
17 Sep 2023
Historique:
received:
19
08
2023
revised:
13
09
2023
accepted:
15
09
2023
medline:
28
9
2023
pubmed:
28
9
2023
entrez:
28
9
2023
Statut:
epublish
Résumé
Ischemic damage to the brain and loss of neurons contribute to functional disabilities in many stroke survivors. Recovery of neuroplasticity is critical to restoration of function and improved quality of life. Stroke and neurological deficits occur in both adults and children, and yet it is well documented that the developing brain has remarkable plasticity which promotes increased post-ischemic functional recovery compared with adults. However, the mechanisms underlying post-stroke recovery in the young brain have not been fully explored. We observed opposing responses to experimental cerebral ischemia in juvenile and adult mice, with substantial neural regeneration and enhanced neuroplasticity detected in the juvenile brain that was not found in adults. We demonstrate strikingly different stroke-induced neuroimmune responses that are deleterious in adults and protective in juveniles, supporting neural regeneration and plasticity. Understanding age-related differences in neuronal repair and regeneration, restoration of neural network function, and neuroimmune signaling in the stroke-injured brain may offer new insights for the development of novel therapeutic strategies for stroke rehabilitation.
Identifiants
pubmed: 37759938
pii: brainsci13091337
doi: 10.3390/brainsci13091337
pmc: PMC10526826
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : NIGMS NIH HHS
ID : P20 GM134974
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS131484
Pays : United States
Organisme : NIGMS NIH HHS
ID : P20GM134974
Pays : United States
Organisme : NINDS NIH HHS
ID : R01NS131484
Pays : United States
Références
Nat Rev Neurol. 2018 Aug;14(8):447-448
pubmed: 29959393
Stem Cells. 2006 Mar;24(3):739-47
pubmed: 16210404
Biomaterials. 2018 Nov;183:200-217
pubmed: 30172245
Crit Care. 2016 Dec 7;20(1):391
pubmed: 27923376
Circulation. 2005 Feb 22;111(7):913-9
pubmed: 15710762
J Cereb Blood Flow Metab. 2012 Aug;32(8):1567-77
pubmed: 22510603
J Neuroinflammation. 2019 Jul 10;16(1):142
pubmed: 31291966
Brain. 2011 Aug;134(Pt 8):2197-221
pubmed: 21784775
J Stroke. 2016 Sep;18(3):256-266
pubmed: 27733032
Physiology (Bethesda). 2015 Sep;30(5):358-70
pubmed: 26328881
Lancet. 2016 Oct 8;388(10053):1545-1602
pubmed: 27733282
J Clin Invest. 2012 Aug;122(8):2711-9
pubmed: 22850880
J Clin Invest. 2005 Aug;115(8):2083-98
pubmed: 16007267
Acta Pharmacol Sin. 2017 Apr;38(4):445-458
pubmed: 28260801
Neurotherapeutics. 2020 Apr;17(2):414-435
pubmed: 32193840
Br J Clin Pharmacol. 2008 Dec;66(6):792-801
pubmed: 19032723
Int J Mol Sci. 2020 Apr 28;21(9):
pubmed: 32354122
J Neuropathol Exp Neurol. 2013 Aug;72(8):718-22
pubmed: 23860031
J Neurosci. 2006 Mar 29;26(13):3491-5
pubmed: 16571756
Nat Rev Neurol. 2017 Jul;13(7):420-433
pubmed: 28524175
Neuropharmacology. 2004 Mar;46(3):404-11
pubmed: 14975696
Neurotherapeutics. 2016 Oct;13(4):791-800
pubmed: 27412685
Ann Neurol. 2007 Mar;61(3):185-6
pubmed: 17387724
Front Cell Neurosci. 2018 Nov 27;12:432
pubmed: 30538622
Stroke. 2013 Mar;44(3):759-63
pubmed: 23349190
Brain Res. 2019 Nov 1;1722:146362
pubmed: 31381876
J Immunol. 2017 Feb 15;198(4):1395-1402
pubmed: 28167650
Acta Neuropathol. 2019 May;137(5):693-714
pubmed: 30483945
Biomedicines. 2022 Dec 20;11(1):
pubmed: 36672510
J Child Neurol. 2014 Jun;29(6):782-8
pubmed: 23589374
J Stroke Cerebrovasc Dis. 2014 Jan;23(1):51-5
pubmed: 23085301
J Neuroinflammation. 2015 May 29;12:106
pubmed: 26022493
Stroke. 2012 Feb;43(2):371-7
pubmed: 22156694
Crit Care. 2012 Dec 12;16(2):216
pubmed: 22429809
CNS Neurosci Ther. 2023 Jul 14;:
pubmed: 37452512
Nat Methods. 2012 Jun 28;9(7):676-82
pubmed: 22743772
Brain Res. 2012 Jan 11;1431:97-106
pubmed: 22137656
Glia. 2016 Nov;64(11):1972-86
pubmed: 27463063
Brain Behav Immun. 2013 Aug;32:70-85
pubmed: 23454862
Stroke. 2013 Aug;44(8):2300-6
pubmed: 23743973
Semin Pediatr Neurol. 2000 Dec;7(4):309-17
pubmed: 11205720
Neurotherapeutics. 2016 Oct;13(4):661-670
pubmed: 27730544
Sci Rep. 2019 Feb 27;9(1):2905
pubmed: 30814573
Arch Phys Med Rehabil. 2009 Apr;90(4):657-62
pubmed: 19345783
Curr Protoc Mol Biol. 2016 Jul 01;115:14.25.1-14.25.14
pubmed: 27366888
Int J Mol Sci. 2015 Oct 26;16(10):25605-40
pubmed: 26516838
Front Cell Dev Biol. 2019 Mar 05;7:24
pubmed: 30891446
Arch Int Pharmacodyn Ther. 1986 Oct;283(2):321-34
pubmed: 3024600
Ann Neurol. 2006 May;59(5):735-42
pubmed: 16634041
Expert Opin Pharmacother. 2009 Dec;10(17):2897-904
pubmed: 19929708
Aging Dis. 2021 Jul 1;12(4):1043-1055
pubmed: 34221548
Annu Rev Neurosci. 2005;28:223-50
pubmed: 16022595
World J Stem Cells. 2023 Mar 26;15(3):52-70
pubmed: 37007453
Oncotarget. 2017 Mar 21;8(12):19855-19865
pubmed: 28423639
Eur J Neurosci. 2021 Sep;54(5):5880-5901
pubmed: 32920880
Blood Cells Mol Dis. 2017 Sep;67:23-33
pubmed: 28336156
Methods Mol Biol. 2014;1135:81-93
pubmed: 24510856
Proc Natl Acad Sci U S A. 2010 Jun 22;107(25):11313-8
pubmed: 20534506
Proc Natl Acad Sci U S A. 2006 Aug 29;103(35):13198-202
pubmed: 16924107
Int J Mol Sci. 2017 Feb 25;18(3):
pubmed: 28245599
J Neurosci. 2015 Jun 17;35(24):9194-204
pubmed: 26085641
Neuroscientist. 2008 Oct;14(5):446-58
pubmed: 18997123
Neurodegener Dis. 2012;9(4):187-98
pubmed: 22584394
J Cereb Blood Flow Metab. 2014 Oct;34(10):1573-84
pubmed: 25074747
Mol Neurobiol. 2010 Jun;41(2-3):232-41
pubmed: 20148316
Cell. 2008 Feb 22;132(4):645-60
pubmed: 18295581
J Neurosci. 2015 Dec 2;35(48):15894-902
pubmed: 26631470
Nat Rev Neurosci. 2001 Oct;2(10):734-44
pubmed: 11584311
Stroke Res Treat. 2018 Nov 27;2018:3238165
pubmed: 30598741
J Cereb Blood Flow Metab. 2006 Jan;26(1):1-20
pubmed: 15959458
Pediatrics. 2018 May;141(5):
pubmed: 29695585
Cell Death Dis. 2018 Feb 14;9(2):250
pubmed: 29445154
Ann Neurol. 2002 Dec;52(6):802-13
pubmed: 12447935
Front Cell Neurosci. 2013 Nov 22;7:229
pubmed: 24319411
Nat Med. 2002 Sep;8(9):963-70
pubmed: 12161747
Mol Cell Neurosci. 2006 Jan;31(1):149-60
pubmed: 16297637
Arzneimittelforschung. 2008;58(6):277-82
pubmed: 18677969
Neuroscience. 2018 Jun 1;380:1-13
pubmed: 29649514
J Neurosci. 2015 Aug 12;35(32):11281-91
pubmed: 26269636
Neurol Res. 1993 Jun;15(3):169-73
pubmed: 8103582
Molecules. 2022 Dec 02;27(23):
pubmed: 36500540
Lancet Neurol. 2021 Oct;20(10):795-820
pubmed: 34487721
Neuroscience. 2007 Jul 29;147(4):867-83
pubmed: 17459594
Nat Rev Immunol. 2005 Aug;5(8):629-40
pubmed: 16034365
Pediatr Neurol. 2020 Jan;102:3-9
pubmed: 31371122