High-Frequency Repetitive Magnetic Stimulation Activates Bactericidal Activity of Macrophages via Modulation of p62/Keap1/Nrf2 and p38 MAPK Pathways.
Keap1
Nrf2
Nrf2 knockout mice
Staphylococcus aureus
THP-1-derived macrophages
alveolar macrophages
p38 MAPK
p62
repetitive magnetic stimulation
Journal
Antioxidants (Basel, Switzerland)
ISSN: 2076-3921
Titre abrégé: Antioxidants (Basel)
Pays: Switzerland
ID NLM: 101668981
Informations de publication
Date de publication:
30 Aug 2023
30 Aug 2023
Historique:
received:
21
07
2023
revised:
09
08
2023
accepted:
16
08
2023
medline:
28
9
2023
pubmed:
28
9
2023
entrez:
28
9
2023
Statut:
epublish
Résumé
The effects of repetitive magnetic stimulation (rMS) have predominantly been studied in excitable cells, with limited research in non-excitable cells. This study aimed to investigate the impact of rMS on macrophages, which are crucial cells in the innate immune defense. THP-1-derived macrophages subjected to a 5 min session of 10 Hz rMS exhibited increased Nrf2 activation and decreased Keap1 expression. We found that activation of the Nrf2 signaling pathway relied on rMS-induced phosphorylation of p62. Notably, rMS reduced the intracellular survival of
Identifiants
pubmed: 37759998
pii: antiox12091695
doi: 10.3390/antiox12091695
pmc: PMC10525279
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : INSERM
ID : not available
Organisme : UVSQ
ID : not available
Organisme : Chancellerie des Universités de Paris
ID : Legs Poix
Références
Mol Cell. 2013 Sep 12;51(5):618-31
pubmed: 24011591
Pharmacol Res. 2018 Aug;134:92-99
pubmed: 29913224
Front Neurosci. 2019 Nov 19;13:1225
pubmed: 31798406
Mol Cell Biol. 2012 Apr;32(8):1506-17
pubmed: 22331464
Infect Immun. 2011 May;79(5):1898-904
pubmed: 21402768
Nature. 2023 Jun;618(7966):698-707
pubmed: 37344646
Cancer Res. 2013 Apr 1;73(7):2199-210
pubmed: 23382044
Mol Cell Biol. 2004 Jan;24(1):36-45
pubmed: 14673141
Life Sci. 2023 Sep 1;328:121857
pubmed: 37307965
J Biol Chem. 2010 Jul 16;285(29):22576-91
pubmed: 20452972
J Proteome Res. 2011 Sep 2;10(9):4018-32
pubmed: 21736355
Int J Mol Sci. 2020 Jul 30;21(15):
pubmed: 32751697
Front Neurol. 2022 May 20;13:793253
pubmed: 35669870
Lancet. 2010 May 1;375(9725):1557-68
pubmed: 20206987
Autophagy. 2021 Jun;17(6):1448-1457
pubmed: 32559122
Nat Cell Biol. 2010 Mar;12(3):213-23
pubmed: 20173742
Front Cell Neurosci. 2022 Apr 12;16:878345
pubmed: 35496902
J Orthop Res. 1988;6(2):259-64
pubmed: 3343631
Front Neurol. 2018 Feb 13;9:50
pubmed: 29487560
Cell Death Discov. 2015 Aug 24;1:15022
pubmed: 27551455
Theranostics. 2020 Oct 26;10(26):12090-12110
pubmed: 33204331
Int J Mol Med. 2020 Jun;45(6):1927-1941
pubmed: 32323751
Clin Infect Dis. 2022 Mar 23;74(6):1070-1080
pubmed: 34617118
Autophagy. 2016 Nov;12(11):2069-2084
pubmed: 27629870
Trends Mol Med. 2011 Jul;17(7):363-71
pubmed: 21459041
Nat Med. 2004 Aug;10(8):842-8
pubmed: 15247912
Infect Immun. 2001 Sep;69(9):5235-42
pubmed: 11500391
J Neurosci. 2023 Apr 26;43(17):3042-3060
pubmed: 36977586
Cell Signal. 2014 Apr;26(4):806-14
pubmed: 24412754
Mol Cell Biol. 2005 Feb;25(3):1089-99
pubmed: 15657435
J Immunol. 2000 Mar 15;164(6):3222-8
pubmed: 10706714