Three Dimensional Models of Endocrine Organs and Target Tissues Regulated by the Endocrine System.
adrenal
breast
endocrine organs
neuroendocrine neoplasia
organoids
ovaries
pancreas
pituitary
prostate
spheroids
thyroid
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
17 Sep 2023
17 Sep 2023
Historique:
received:
26
06
2023
revised:
28
08
2023
accepted:
14
09
2023
medline:
28
9
2023
pubmed:
28
9
2023
entrez:
28
9
2023
Statut:
epublish
Résumé
Immortalized cell lines originating from tumors and cultured in monolayers in vitro display consistent behavior and response, and generate reproducible results across laboratories. However, for certain endpoints, these cell lines behave quite differently from the original solid tumors. Thereby, the homogeneity of immortalized cell lines and two-dimensionality of monolayer cultures deters from the development of new therapies and translatability of results to the more complex situation in vivo. Organoids originating from tissue biopsies and spheroids from cell lines mimic the heterogeneous and multidimensional characteristics of tumor cells in 3D structures in vitro. Thus, they have the advantage of recapitulating the more complex tissue architecture of solid tumors. In this review, we discuss recent efforts in basic and preclinical cancer research to establish methods to generate organoids/spheroids and living biobanks from endocrine tissues and target organs under endocrine control while striving to achieve solutions in personalized medicine.
Identifiants
pubmed: 37760571
pii: cancers15184601
doi: 10.3390/cancers15184601
pmc: PMC10526768
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
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