Clonal, Plasmidic and Genetic Diversity of Multi-Drug-Resistant Enterobacterales from Hospitalized Patients in Tripoli, Libya.
E. coli
K. pneumoniae
KPC-2
NDM-1
OXA-48
amikacin
carbapenem
colistin
nosocomial infection
Journal
Antibiotics (Basel, Switzerland)
ISSN: 2079-6382
Titre abrégé: Antibiotics (Basel)
Pays: Switzerland
ID NLM: 101637404
Informations de publication
Date de publication:
10 Sep 2023
10 Sep 2023
Historique:
received:
29
07
2023
revised:
01
09
2023
accepted:
06
09
2023
medline:
28
9
2023
pubmed:
28
9
2023
entrez:
28
9
2023
Statut:
epublish
Résumé
Resistance to extended-spectrum cephalosporins (ESC) and carbapenems in Enterobacterales is a major issue in public health. Carbapenem resistance in particular is associated with increased morbidity and mortality. Moreover, such resistance is often co-harbored with resistance to non-beta-lactam antibiotics, and pathogens quickly become multi-drug-resistant (MDR). Only a few studies have been published on AMR in Libyan hospitals, but all reported worrisome results. Here, we studied 54 MDR isolates that were collected from 49 patients at the Tripoli University Hospital between 2019 and 2021. They were characterized using phenotypic methods, PCR and PFGE, and a sub-set of isolates were short- and long-read whole-genome sequenced. The results showed the frequent occurrence of
Identifiants
pubmed: 37760726
pii: antibiotics12091430
doi: 10.3390/antibiotics12091430
pmc: PMC10525897
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : French Agency for Food, Environmental and Occupational Health & Safety
ID : no grant number
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