Long-Term Efficacy of Mepolizumab at 3 Years in Patients with Severe Asthma: Comparison with Clinical Trials and Super Responders.
CRSwNP
IL-5
eosinophils
mepolizumab
real life
registry
severe asthma
Journal
Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304
Informations de publication
Date de publication:
30 Aug 2023
30 Aug 2023
Historique:
received:
11
05
2023
revised:
23
06
2023
accepted:
04
08
2023
medline:
28
9
2023
pubmed:
28
9
2023
entrez:
28
9
2023
Statut:
epublish
Résumé
The efficacy mepolizumab in severe asthmatic patients is proven in the literature. Primarily to study the effect of mepolizumab on exacerbations, steroid dependence, and the continuation of efficacy in the long term. Secondarily to evaluate the effect of the drug on nasal polyps. Analyzing data from SANI (Severe Asthma Network Italy) clinics, we observed severe asthmatic patients treated with mepolizumab 100 mg/4 weeks, for a period of 3 years. 157 patients were observed. Exacerbations were reduced from the first year (-84.6%) and progressively to 90 and 95% in the second and third ones. Steroid-dependent patients decreased from 54% to 21% and subsequently to 11% in the second year and 6% in the third year. Patients with concomitant nasal polyps, assessed by SNOT-22, showed a 49% reduction in value from baseline to the third year. The study demonstrated the long-term efficacy of mepolizumab in a real-life setting.
Identifiants
pubmed: 37760865
pii: biomedicines11092424
doi: 10.3390/biomedicines11092424
pmc: PMC10525371
pii:
doi:
Types de publication
Journal Article
Langues
eng
Références
J Asthma. 2023 Jan;60(1):158-166
pubmed: 35112934
ERJ Open Res. 2021 Jun 07;7(2):
pubmed: 34109244
N Engl J Med. 2009 Mar 5;360(10):985-93
pubmed: 19264687
Ann Allergy Asthma Immunol. 2021 Apr;126(4):438-440
pubmed: 33453381
Am J Respir Crit Care Med. 2009 Sep 1;180(5):388-95
pubmed: 19483109
World Allergy Organ J. 2019 Jan 26;12(1):100007
pubmed: 30937132
Lancet. 2012 Aug 18;380(9842):651-9
pubmed: 22901886
Eur Respir J. 2014 Feb;43(2):343-73
pubmed: 24337046
Clin Ther. 2016 Sep;38(9):2058-2070.e1
pubmed: 27553751
Pulm Pharmacol Ther. 2018 Dec;53:1-5
pubmed: 30217438
Allergy. 2022 Dec;77(12):3538-3552
pubmed: 35950646
Chest. 2020 Aug;158(2):491-500
pubmed: 32275980
Pulm Pharmacol Ther. 2019 Oct;58:101836
pubmed: 31473366
Respir Res. 2001;2(2):71-9
pubmed: 11686868
J Asthma Allergy. 2015 Oct 08;8:105-14
pubmed: 26504401
Eur Respir Rev. 2020 Jun 3;29(156):
pubmed: 32499305
J Asthma Allergy. 2018 Aug 29;11:193-204
pubmed: 30214247
Ther Adv Respir Dis. 2021 Jan-Dec;15:17534666211009398
pubmed: 33910399
N Engl J Med. 2014 Sep 25;371(13):1198-207
pubmed: 25199059
Allergy. 2020 May;75(5):1023-1042
pubmed: 32034960
Cell Signal. 2020 May;69:109523
pubmed: 31904412
Epigenomics. 2017 Apr;9(4):539-571
pubmed: 28322581
Clin Ther. 2019 Oct;41(10):2041-2056.e5
pubmed: 31447130
Respir Med. 2020 May;166:105947
pubmed: 32250875
N Engl J Med. 2014 Sep 25;371(13):1189-97
pubmed: 25199060
Eur Respir J. 2022 Jan 6;59(1):
pubmed: 34172470
Am J Respir Crit Care Med. 2019 Feb 15;199(4):433-445
pubmed: 30525902
Allergy. 2020 Jun;75(6):1460-1463
pubmed: 31773742
Clin Transl Allergy. 2021 Oct 14;11(8):e12067
pubmed: 34691389
World Allergy Organ J. 2018 Dec 06;11(1):34
pubmed: 30555618
World Allergy Organ J. 2021 Jan 27;14(2):100509
pubmed: 33598095
Clin Otolaryngol. 2009 Oct;34(5):447-54
pubmed: 19793277
Adv Ther. 2018 Nov;35(11):1763-1774
pubmed: 30357570
N Engl J Med. 2009 Mar 5;360(10):973-84
pubmed: 19264686
J Allergy Clin Immunol Pract. 2019 May - Jun;7(5):1462-1468
pubmed: 30368004
Nat Rev Immunol. 2015 Jan;15(1):57-65
pubmed: 25534623
Int Forum Allergy Rhinol. 2017 Dec;7(12):1149-1155
pubmed: 29053911
Allergy. 2019 Dec;74(12):2539-2541
pubmed: 31166605
Int J Mol Sci. 2021 Apr 26;22(9):
pubmed: 33926084
J Asthma. 2022 Nov;59(11):2201-2217
pubmed: 34951336
Eur Respir J. 2020 Oct 15;56(4):
pubmed: 32817259
Rhinology. 2021 Feb 1;59(1):110-112
pubmed: 33320921
Allergy. 2019 Feb;74(2):273-283
pubmed: 29987879
J Allergy Clin Immunol Pract. 2022 Oct;10(10):2646-2656
pubmed: 35753668