Citrus Extract High in Flavonoids Beneficially Alters Intestinal Metabolic Responses in Subjects with Features of Metabolic Syndrome.
TIM-2
citrus extract
in vitro model
metabolic syndrome
short-chain fatty acids (SCFAs)
Journal
Foods (Basel, Switzerland)
ISSN: 2304-8158
Titre abrégé: Foods
Pays: Switzerland
ID NLM: 101670569
Informations de publication
Date de publication:
13 Sep 2023
13 Sep 2023
Historique:
received:
31
08
2023
revised:
08
09
2023
accepted:
11
09
2023
medline:
28
9
2023
pubmed:
28
9
2023
entrez:
28
9
2023
Statut:
epublish
Résumé
The objective of this study was to investigate the effects of a citrus extract rich in citrus flavonoids on intestinal metabolic responses in subjects with features of metabolic syndrome, in an in vitro colon fermentation system (TIM-2) and fecal samples obtained from human subjects in an in vivo trial. In the TIM-2 system inoculated with fecal samples of volunteers with features of metabolic syndrome, continuous citrus extract supplementation (500 mg/day) resulted in increased cumulative short-chain fatty acid (SCFA) levels compared to the control condition, which was mainly due to increased production of butyrate, acetate, and valerate. In human volunteers, 12 weeks of daily supplementation with 500 mg citrus extract resulted in a significant shift in the SCFA profile towards more butyrate (
Identifiants
pubmed: 37761122
pii: foods12183413
doi: 10.3390/foods12183413
pmc: PMC10529306
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : BioActor (Netherlands)
ID : n/a
Organisme : Dutch Province of Limburg
ID : HEFI-1
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