Pulmonary Sarcoidosis and Immune Dysregulation: A Pilot Study on Possible Correlation.
immune dysregulation
lymphocyte typing
lymphopenia
sarcoidosis
severity index
Journal
Diagnostics (Basel, Switzerland)
ISSN: 2075-4418
Titre abrégé: Diagnostics (Basel)
Pays: Switzerland
ID NLM: 101658402
Informations de publication
Date de publication:
11 Sep 2023
11 Sep 2023
Historique:
received:
02
08
2023
revised:
01
09
2023
accepted:
06
09
2023
medline:
28
9
2023
pubmed:
28
9
2023
entrez:
28
9
2023
Statut:
epublish
Résumé
Sarcoidosis is a systemic inflammatory disease characterized by an altered inflammatory response. The aim of this study was to evaluate whether immune system alterations detected by lymphocyte typing in peripheral blood correlate with the severity of sarcoidosis, calculated according to two separate severity scores proposed by Wasfi in 2006 and Hamzeh in 2010. Eighty-one patients were recruited, and clinical data and laboratory tests at the time of diagnosis were obtained in order to assess the severity index score and investigate any statistically significant correlation with the cytofluorimetry data. Our data demonstrated that none of the two scores show an association with the level of total lymphocytes or lymphocyte subclasses. First of all, the sample taken into consideration is small. The assessment was performed only at disease onset and not during the disease. Furthermore, the severity scores do not take into account disease activity (measured by PET/CT or gallium scintigraphy). Lymphocyte subpopulation values at the time of diagnosis do not appear to correlate with disease severity at onset.
Sections du résumé
BACKGROUND
BACKGROUND
Sarcoidosis is a systemic inflammatory disease characterized by an altered inflammatory response.
OBJECTIVE
OBJECTIVE
The aim of this study was to evaluate whether immune system alterations detected by lymphocyte typing in peripheral blood correlate with the severity of sarcoidosis, calculated according to two separate severity scores proposed by Wasfi in 2006 and Hamzeh in 2010.
MATERIALS AND METHODS
METHODS
Eighty-one patients were recruited, and clinical data and laboratory tests at the time of diagnosis were obtained in order to assess the severity index score and investigate any statistically significant correlation with the cytofluorimetry data.
RESULTS
RESULTS
Our data demonstrated that none of the two scores show an association with the level of total lymphocytes or lymphocyte subclasses.
LIMITATIONS
CONCLUSIONS
First of all, the sample taken into consideration is small. The assessment was performed only at disease onset and not during the disease. Furthermore, the severity scores do not take into account disease activity (measured by PET/CT or gallium scintigraphy).
CONCLUSIONS
CONCLUSIONS
Lymphocyte subpopulation values at the time of diagnosis do not appear to correlate with disease severity at onset.
Identifiants
pubmed: 37761266
pii: diagnostics13182899
doi: 10.3390/diagnostics13182899
pmc: PMC10530165
pii:
doi:
Types de publication
Journal Article
Langues
eng
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