Pediatric Spinal Cord Injury: A Review.
neuroregeneration
non-traumatic spinal cord injury
rehabilitation
spinal cord dysfunction
spinal cord injury
traumatic spinal cord injury
Journal
Children (Basel, Switzerland)
ISSN: 2227-9067
Titre abrégé: Children (Basel)
Pays: Switzerland
ID NLM: 101648936
Informations de publication
Date de publication:
26 Aug 2023
26 Aug 2023
Historique:
received:
24
06
2023
revised:
14
08
2023
accepted:
23
08
2023
medline:
28
9
2023
pubmed:
28
9
2023
entrez:
28
9
2023
Statut:
epublish
Résumé
A spinal cord injury (SCI) can be a devastating condition in children, with profound implications for their overall health and quality of life. In this review, we aim to provide a concise overview of the key aspects associated with SCIs in the pediatric population. Firstly, we discuss the etiology and epidemiology of SCIs in children, highlighting the diverse range of causes. We explore the unique anatomical and physiological characteristics of the developing spinal cord that contribute to the specific challenges faced by pediatric patients. Next, we delve into the clinical presentation and diagnostic methods, emphasizing the importance of prompt and accurate diagnosis to facilitate appropriate interventions. Furthermore, we approach the multidisciplinary management of pediatric SCIs, encompassing acute medical care, surgical interventions, and ongoing supportive therapies. Finally, we explore emerging research as well as innovative therapies in the field, and we emphasize the need for continued advancements in understanding and treating SCIs in children to improve their functional independence and overall quality of life.
Identifiants
pubmed: 37761417
pii: children10091456
doi: 10.3390/children10091456
pmc: PMC10530251
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Références
Phys Med Rehabil Clin N Am. 2000 Feb;11(1):169-82
pubmed: 10680164
AJR Am J Roentgenol. 2009 May;192(5):1292-303
pubmed: 19380554
J Neuropathol Exp Neurol. 2005 Sep;64(9):763-9
pubmed: 16141785
Spine (Phila Pa 1976). 2004 Jul 1;29(13):1493-7; discussion E266
pubmed: 15223946
Arch Phys Med Rehabil. 2015 Jan;96(1):133-40
pubmed: 25220943
Neurobiol Dis. 2022 Oct 1;172:105812
pubmed: 35810963
JAMA. 2015 Jun 9;313(22):2236-43
pubmed: 26057284
J Neurosci. 2007 Sep 5;27(36):9545-59
pubmed: 17804616
Phys Med Rehabil Clin N Am. 2015 Feb;26(1):109-32
pubmed: 25479784
Emerg Radiol. 2021 Feb;28(1):127-141
pubmed: 32601894
J Spinal Cord Med. 2014 Sep;37(5):511-24
pubmed: 25229735
J Pediatr Orthop. 2005 Jul-Aug;25(4):484-6
pubmed: 15958900
Neurosurgery. 2018 Apr 1;82(4):562-575
pubmed: 28541431
World Neurosurg. 2018 Aug;116:e867-e873
pubmed: 29807180
Neurobiol Dis. 2021 Jul;155:105385
pubmed: 33991647
J Spinal Cord Med. 2014 Jan;37(1):2-10
pubmed: 24090418
Neurosurgery. 2020 Jul 1;87(1):E1-E9
pubmed: 32374883
J Neurosci. 1996 May 15;16(10):3199-208
pubmed: 8627358
Rehabil Nurs. 1991 May-Jun;16(3):122-7
pubmed: 2034877
Arch Phys Med Rehabil. 1996 Oct;77(10):1005-13
pubmed: 8857878
Lancet. 2017 May 6;389(10081):1821-1830
pubmed: 28363483
Development. 2019 Feb 18;146(4):
pubmed: 30777863
Neurotrauma Rep. 2020 Sep 18;1(1):78-87
pubmed: 34223533
Skeletal Radiol. 2016 Dec;45(12):1607-1617
pubmed: 27650073
J Neurosurg Spine. 2018 Dec 20;30(1):1-18
pubmed: 30611186
Neurobiol Dis. 2020 Sep;143:104995
pubmed: 32590037
J Neuropathol Exp Neurol. 2007 Aug;66(8):724-31
pubmed: 17882016
Neurosurgery. 2004 Dec;55(6):1325-42; discussion 1342-3
pubmed: 15574214
Dev Med Child Neurol. 2012 Dec;54(12):1138-43
pubmed: 22998495
Arch Phys Med Rehabil. 1978 Oct;59(10):443-6
pubmed: 718406
J Neurotrauma. 2014 Feb 1;31(3):239-55
pubmed: 23859435
Neurosurgery. 2013 Aug;60(CN_suppl_1):82-91
pubmed: 23839357
J Neurotrauma. 2020 Feb 1;37(3):448-457
pubmed: 31310155
Nat Neurosci. 2017 Apr 25;20(5):637-647
pubmed: 28440805
Dev Med Child Neurol. 1995 Nov;37(11):957-64
pubmed: 8566456
Spinal Cord. 2005 Dec;43(12):713-23
pubmed: 16010275
Global Spine J. 2020 Oct;10(7):826-831
pubmed: 32905717
Pediatr Emerg Care. 2011 Dec;27(12):1192-4
pubmed: 22158284
J Clin Imaging Sci. 2015 Jun 30;5:38
pubmed: 26199787
Pediatr Rehabil. 2005 Jan-Mar;8(1):63-6
pubmed: 15799138
J Pediatr Surg. 2013 Jun;48(6):1413-21
pubmed: 23845640
Brain. 2021 Apr 12;144(3):789-799
pubmed: 33764445
PLoS Biol. 2016 May 31;14(5):e1002468
pubmed: 27244556
J Spinal Cord Med. 2008;31(2):215-21
pubmed: 18581671
Neurology. 2017 Oct 17;89(16):1660-1667
pubmed: 28916535
Front Genet. 2016 Dec 20;7:213
pubmed: 28066501
J Spinal Cord Med. 2004;27 Suppl 1:S80-3
pubmed: 15503707
J Pediatr Rehabil Med. 2013;6(1):45-52
pubmed: 23481891
J Neurosurg Pediatr. 2011 Sep;8(3):235-43
pubmed: 21882912
N Engl J Med. 2007 Nov 29;357(22):2277-84
pubmed: 18046031
Top Spinal Cord Inj Rehabil. 2022 Spring;28(2):13-90
pubmed: 35521053
J Pediatr Surg. 2001 Aug;36(8):1107-14
pubmed: 11479837
J Neurotrauma. 2011 Aug;28(8):1515-24
pubmed: 21501096
J Trauma. 2009 Sep;67(3):537-42
pubmed: 19741397
Spinal Cord. 2021 Dec;59(12):1240-1246
pubmed: 34455422
Arch Intern Med. 1998 Mar 23;158(6):585-93
pubmed: 9521222
Radiographics. 2019 Jul-Aug;39(4):1126-1142
pubmed: 31173542
J Bone Joint Surg Am. 1978 Oct;60(7):921-4
pubmed: 701339
J Bone Joint Surg Am. 1977 Jan;59(1):37-44
pubmed: 833172
Ann Emerg Med. 1996 Jul;28(1):55-74
pubmed: 8669740
AJR Am J Roentgenol. 2011 May;196(5):1003-10
pubmed: 21512064
Ann N Y Acad Sci. 2010 Jun;1198 Suppl 1:E22-34
pubmed: 20590535
Evid Based Spine Care J. 2012 Feb;3(1):19-26
pubmed: 23236302
Nat Rev Dis Primers. 2017 Apr 27;3:17018
pubmed: 28447605
Spinal Cord. 2008 Jul;46(7):517-22
pubmed: 18317488
J Bone Joint Surg Am. 2019 Jan 2;101(1):e1
pubmed: 30601421
Clin Radiol. 1999 Jun;54(6):377-80
pubmed: 10406338
Med Biol Eng Comput. 2002 Sep;40(5):588-93
pubmed: 12452421
J Neurosci. 2006 Mar 29;26(13):3377-89
pubmed: 16571744
J Neurotrauma. 2011 Aug;28(8):1371-99
pubmed: 20001726
Global Spine J. 2017 Sep;7(3 Suppl):84S-94S
pubmed: 29164036
Handb Clin Neurol. 2016;136:1199-220
pubmed: 27430465
J Spinal Cord Med. 2007;30 Suppl 1:S21-4
pubmed: 17874682
BMJ Case Rep. 2017 Oct 10;2017:
pubmed: 29021141
Acad Emerg Med. 2001 Mar;8(3):237-45
pubmed: 11229945
Arch Dis Child. 2003 Apr;88(4):335-6
pubmed: 12651763
Nat Neurosci. 1999 Jul;2(7):664-70
pubmed: 10404201
J Neurosurg Pediatr. 2017 Dec;20(6):567-574
pubmed: 28984538
Folia Morphol (Warsz). 2013 Aug;72(3):230-8
pubmed: 24068685
Ann Emerg Med. 1994 Feb;23(2):208-11
pubmed: 8304600
Rev Neurosci. 2015;26(2):121-8
pubmed: 25581750
Brain Res. 2005 Feb 21;1035(1):73-85
pubmed: 15713279
Cell Transplant. 2019 Jan;28(1):36-46
pubmed: 30362373
J Spinal Cord Med. 2001 Winter;24(4):278-83
pubmed: 11944786
J Neurosurg Spine. 2021 Sep 17;36(1):153-159
pubmed: 34534962
Nature. 2016 Apr 13;533(7602):247-50
pubmed: 27074513
Front Neurosci. 2018 Apr 06;12:227
pubmed: 29681792
J Am Coll Radiol. 2008 Feb;5(2):78-9
pubmed: 18242519
J Spinal Cord Med. 1998 Oct;21(4):335-41
pubmed: 10096046
J Spinal Cord Med. 2002 Summer;25(2):106-16
pubmed: 12137214
Pediatr Phys Ther. 2010 Summer;22(2):214-21
pubmed: 20473107
Radiographics. 2015 Nov-Dec;35(7):2121-34
pubmed: 26562241
J Pathol. 2010 Jan;220(2):217-30
pubmed: 19918803
Arch Phys Med Rehabil. 2011 Aug;92(8):1264-9
pubmed: 21807145
J Neuroimaging. 2015 May-Jun;25(3):337-53
pubmed: 25512255
Neuroscientist. 2005 Oct;11(5):400-7
pubmed: 16151042
Neurosurgery. 2010 Mar;66(3 Suppl):22-31
pubmed: 20173524
Neurosurgery. 2007 Sep;61(3):514-21; discussion 521
pubmed: 17881963
Neurosurgery. 2013 Mar;72 Suppl 2:227-33
pubmed: 23417193
J Pediatr Surg. 1994 Nov;29(11):1409-11
pubmed: 7844708
Radiology. 1993 Aug;188(2):523-6
pubmed: 8327708
Acta Biomater. 2016 Sep 15;42:77-89
pubmed: 27296842
J Spinal Cord Med. 2002 Winter;25(4):345-50
pubmed: 12482180
Int Orthop. 2007 Jun;31(3):375-83
pubmed: 16835743
Neurorehabil Neural Repair. 2020 Aug;34(8):758-768
pubmed: 32698674
AJR Am J Roentgenol. 2001 Feb;176(2):289-96
pubmed: 11159059
Nat Rev Neurosci. 2004 Feb;5(2):146-56
pubmed: 14735117
Front Cell Dev Biol. 2017 Jan 19;4:152
pubmed: 28154814
Childs Nerv Syst. 2007 Sep;23(9):971-9
pubmed: 17605017
Mol Med Rep. 2021 Jun;23(6):
pubmed: 33846780
Radiographics. 2003 Nov-Dec;23(6):1699-701; author reply 1699-701
pubmed: 14615574
J Trauma. 1996 Mar;40(3):408-11
pubmed: 8601858
Int J Pediatr Otorhinolaryngol. 2007 Dec;71(12):1823-7
pubmed: 17706297
Spinal Cord. 2003 Jul;41(7):369-78
pubmed: 12815368
J Spinal Cord Med. 2017 Nov;40(6):665-675
pubmed: 28571527
Pediatrics. 2001 Aug;108(2):E20
pubmed: 11483830
J Spinal Disord. 1991 Sep;4(3):296-305
pubmed: 1802160
J Spinal Cord Med. 2004;27 Suppl 1:S54-60
pubmed: 15503704
Chin J Traumatol. 2023 Jan;26(1):8-13
pubmed: 35478089
Top Spinal Cord Inj Rehabil. 2016 Summer;22(3):209-240
pubmed: 29339863
J Orthop Trauma. 2017 Sep;31 Suppl 4:S7-S13
pubmed: 28816870
Nature. 2012 May 16;485(7398):372-5
pubmed: 22596161
J Neurosurg Spine. 2022 Jul 08;37(6):812-820
pubmed: 35901693
Spinal Cord. 2006 Jun;44(6):357-61
pubmed: 16249784
Nature. 1995 Nov 30;378(6556):498-501
pubmed: 7477407
BMC Neurol. 2019 Jun 24;19(1):140
pubmed: 31234791
Curr Top Dev Biol. 2015;112:197-231
pubmed: 25733141
Spine (Phila Pa 1976). 2001 Dec 15;26(24 Suppl):S87-98
pubmed: 11805614
Brain Sci. 2023 Apr 22;13(5):
pubmed: 37239175
AJR Am J Roentgenol. 2020 Jun;214(6):1359-1368
pubmed: 32228329
Adv J Emerg Med. 2019 Oct 10;4(2):e28
pubmed: 32322796
Nat Rev Neurol. 2019 Dec;15(12):718-731
pubmed: 31673093
Mayo Clin Proc. 1981 Oct;56(10):614-22
pubmed: 7278373
J Neurosurg. 1991 Jul;75(1):15-26
pubmed: 2045903
World Neurosurg. 2018 Jun;114:e247-e253
pubmed: 29530700
J Neurotrauma. 2023 Sep;40(17-18):1878-1888
pubmed: 37279301
Eur Spine J. 2015 May;24(5):919-30
pubmed: 25001890
J Pediatr Intensive Care. 2015 Mar;4(1):27-34
pubmed: 31110847
Chest. 2012 Feb;141(2 Suppl):e737S-e801S
pubmed: 22315277
Int J Mol Sci. 2020 Oct 13;21(20):
pubmed: 33066029
J Neurotrauma. 2015 Nov 1;32(21):1633-44
pubmed: 26192071
Eur Spine J. 2016 Jul;25(7):2173-84
pubmed: 25716661
Pract Neurol. 2021 Dec;21(6):532-538
pubmed: 34353860
J Bone Joint Surg Am. 1993 Jul;75(7):988-95
pubmed: 8335674
J Neurotrauma. 2019 Mar 19;36(6):891-902
pubmed: 30180779
Pediatr Radiol. 1995 Nov;25 Suppl 1:S129-33
pubmed: 8577504
J Neurosci. 2015 Apr 29;35(17):6714-30
pubmed: 25926450
Biomaterials. 2006 Apr;27(11):2370-9
pubmed: 16325904
Arch Phys Med Rehabil. 2009 Aug;90(8):1379-88
pubmed: 19651272
Pediatr Phys Ther. 2008 Summer;20(2):146-51
pubmed: 18480713
J Spinal Cord Med. 2004;27 Suppl 1:S16-23
pubmed: 15503698
Spine J. 2014 Dec 1;14(12):2847-53
pubmed: 24704677
Biomaterials. 2014 Mar;35(9):2617-29
pubmed: 24406216
Neuroscience. 2008 Aug 26;155(3):760-70
pubmed: 18588947
J Comp Neurol. 2007 Jun 1;502(4):644-59
pubmed: 17394135
Spec Care Dentist. 2009 Nov-Dec;29(6):254-8
pubmed: 19886938
Arch Phys Med Rehabil. 1999 Sep;80(9):1047-53
pubmed: 10489007
Molecules. 2015 Apr 29;20(5):7775-89
pubmed: 25939067
J Spinal Cord Med. 2007;30 Suppl 1:S105-11
pubmed: 17874695
Neural Regen Res. 2014 Oct 15;9(20):1850-8
pubmed: 25422649
Neurosurgery. 2013 Mar;72 Suppl 2:205-26
pubmed: 23417192
Spinal Cord. 2002 Dec;40(12):666-8
pubmed: 12483501
Front Pediatr. 2020 Sep 29;8:514
pubmed: 33117760
J Neurosurg Case Lessons. 2023 Mar 6;5(10):
pubmed: 36880507
Proc Natl Acad Sci U S A. 2004 Dec 21;101(51):17849-54
pubmed: 15585584
Spinal Cord. 2016 Mar;54(3):204-12
pubmed: 26078233
J Neurosurg Pediatr. 2010 Mar;5(3):292-6
pubmed: 20192648
Brain Res. 2007 May 29;1149:223-31
pubmed: 17391650
Curr Opin Pediatr. 2017 Jun;29(3):286-290
pubmed: 28306628
Chin J Traumatol. 2023 Jan;26(1):2-7
pubmed: 36137934
Clin Pediatr (Phila). 1995 Feb;34(2):90-5
pubmed: 7729113
Neurosurgery. 2010 Apr;66(4):670-7
pubmed: 20190669
NeuroRehabilitation. 2012;31(4):401-7
pubmed: 23232164
Asian J Neurosurg. 2018 Jul-Sep;13(3):656-659
pubmed: 30283521
Auton Neurosci. 2018 Jan;209:59-70
pubmed: 28506502
Curr Treat Options Neurol. 2022;24(7):285-304
pubmed: 35702419
Neurosurgery. 2002 Mar;50(3 Suppl):S85-99
pubmed: 12431292
Curr Gastroenterol Rep. 2018 Aug 29;20(10):47
pubmed: 30159690
J Neurosurg. 1988 Jan;68(1):18-24
pubmed: 3335907
Arch Intern Med. 1991 May;151(5):933-8
pubmed: 2025141
Am J Stem Cells. 2013 Mar 08;2(1):22-38
pubmed: 23671814
J Trauma. 1999 Nov;47(5):896-902; discussion 902-3
pubmed: 10568719
AJNR Am J Neuroradiol. 2012 Nov;33(10):1882-7
pubmed: 22576894
J Neurosurg Spine. 2018 Jul;29(1):97-107
pubmed: 29701561
Pediatr Phys Ther. 2015 Summer;27(2):190-9
pubmed: 25822361
Int J Crit Illn Inj Sci. 2012 Sep;2(3):114-20
pubmed: 23181204
Pediatrics. 2014 May;133(5):e1179-88
pubmed: 24777222
Arch Phys Med Rehabil. 2005 Dec;86(12):2240-7
pubmed: 16344018
J Spinal Cord Med. 2007;30 Suppl 1:S88-96
pubmed: 17874693
Nat Rev Dis Primers. 2017 Feb 16;3:17002
pubmed: 28205574
BJU Int. 2007 Sep;100(3):639-45
pubmed: 17532858
Biomaterials. 2013 May;34(15):3775-83
pubmed: 23465486
Neurosurg Clin N Am. 2007 Jul;18(3):463-78
pubmed: 17678749
Pediatr Neurosci. 1989;15(1):13-7
pubmed: 2635769
PLoS One. 2011;6(11):e27079
pubmed: 22073257
Exp Neurol. 2014 Aug;258:121-129
pubmed: 25017893
J Comp Neurol. 2009 Jun 10;514(5):433-48
pubmed: 19350644
J Child Orthop. 2008 Mar;2(2):71-84
pubmed: 19308585
J Anaesthesiol Clin Pharmacol. 2014 Jan;30(1):10-8
pubmed: 24574586
Eur J Phys Rehabil Med. 2012 Mar;48(1):111-21
pubmed: 22543557
Indian J Orthop. 2018 Sep-Oct;52(5):489-500
pubmed: 30237606