Thymoquinone Potentially Modulates the Expression of Key Onco- and Tumor Suppressor miRNAs in Prostate and Colon Cancer Cell Lines: Insights from PC3 and HCT-15 Cells.
HCT-15
PC3
colorectal cancer
microRNAs
prostate cancer
thymoquinone
Journal
Genes
ISSN: 2073-4425
Titre abrégé: Genes (Basel)
Pays: Switzerland
ID NLM: 101551097
Informations de publication
Date de publication:
30 08 2023
30 08 2023
Historique:
received:
20
07
2023
revised:
26
08
2023
accepted:
28
08
2023
medline:
4
10
2023
pubmed:
28
9
2023
entrez:
28
9
2023
Statut:
epublish
Résumé
Prostate cancer (PC) and colon cancer significantly contribute to global cancer-related morbidity and mortality. Thymoquinone (TQ), a naturally occurring phytochemical found in black cumin, has shown potential as an anticancer compound. This study aimed to investigate the effects of TQ on the expression profile of key tumor suppressor and onco-suppressor miRNAs in PC3 prostate cancer cells and HCT-15 colon cancer cells. Cell viability assays revealed that TQ inhibited the growth of both cell lines in a dose-dependent manner, with IC
Identifiants
pubmed: 37761870
pii: genes14091730
doi: 10.3390/genes14091730
pmc: PMC10531155
pii:
doi:
Substances chimiques
MicroRNAs
0
thymoquinone
O60IE26NUF
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Références
PLoS One. 2020 Feb 12;15(2):e0228575
pubmed: 32049961
Pathol Res Pract. 2022 Dec;240:154143
pubmed: 36347210
Pharmaceuticals (Basel). 2021 Apr 16;14(4):
pubmed: 33923474
J Oncol. 2020 Jul 3;2020:9160905
pubmed: 32714393
Front Oncol. 2022 Sep 08;12:965231
pubmed: 36158660
Gene. 2020 May 15;738:144453
pubmed: 32035242
Phytother Res. 2021 Jul;35(7):3732-3746
pubmed: 33724576
Andrologia. 2021 Jun;53(5):e14016
pubmed: 33598946
Cancers (Basel). 2021 May 29;13(11):
pubmed: 34072348
Cell Death Dis. 2017 Oct 12;8(10):e3100
pubmed: 29022903
Mol Cancer. 2010 Jan 21;9:12
pubmed: 20092645
J BUON. 2018 Jan-Feb;23(1):73-78
pubmed: 29552763
Oncotarget. 2016 Nov 8;7(45):73739-73753
pubmed: 27650539
World J Oncol. 2019 Apr;10(2):63-89
pubmed: 31068988
Nutrients. 2019 Jun 29;11(7):
pubmed: 31261861
Cancers (Basel). 2022 Jun 29;14(13):
pubmed: 35804962
Sci Rep. 2017 Oct 13;7(1):13131
pubmed: 29030590
Front Bioeng Biotechnol. 2020 Mar 10;8:176
pubmed: 32211396
Cancer Biomark. 2017 Dec 12;21(1):135-144
pubmed: 29060932
Int J Mol Sci. 2022 Sep 29;23(19):
pubmed: 36232799
Oncol Lett. 2019 Sep;18(3):3274-3282
pubmed: 31452805
Asian Pac J Cancer Prev. 2021 Mar 01;22(3):879-885
pubmed: 33773553
BMC Cancer. 2019 Jun 25;19(1):627
pubmed: 31238903
Cell Mol Life Sci. 2018 Oct;75(19):3539-3551
pubmed: 30030592
Front Genet. 2020 Mar 20;11:192
pubmed: 32265979
J Cancer Prev. 2020 Sep 30;25(3):136-151
pubmed: 33033708
Biology (Basel). 2023 Jun 02;12(6):
pubmed: 37372097
Drug Discov Today. 2019 Dec;24(12):2315-2322
pubmed: 31541714
Int J Clin Exp Pathol. 2019 Mar 01;12(3):808-816
pubmed: 31933888
Mol Ther Nucleic Acids. 2022 Feb 11;27:1191-1224
pubmed: 35282417
Pharmaceuticals (Basel). 2020 Sep 14;13(9):
pubmed: 32937907
Pharmaceutics. 2022 Nov 01;14(11):
pubmed: 36365177
Biochem Cell Biol. 2019 Apr;97(2):91-99
pubmed: 30681889
Urol Oncol. 2020 Jul;38(7):623-635
pubmed: 32284256
Front Oncol. 2020 Oct 27;10:577653
pubmed: 33194696
Cell Death Dis. 2018 Nov 21;9(12):1157
pubmed: 30464258
Adv Pharm Bull. 2019 Aug;9(3):490-496
pubmed: 31592099
Front Plant Sci. 2017 Mar 07;8:307
pubmed: 28326094
Oncotarget. 2020 Aug 04;11(31):2959-2972
pubmed: 32821342
Ann Med. 2021 Dec;53(1):87-102
pubmed: 33108223
Cancers (Basel). 2019 Sep 18;11(9):
pubmed: 31540423
SAGE Open Med. 2021 Aug 12;9:20503121211034366
pubmed: 34408877
Phytother Res. 2022 Feb;36(2):705-729
pubmed: 34932245
Am J Cancer Res. 2018 Oct 01;8(10):2088-2095
pubmed: 30416858
Molecules. 2022 Sep 05;27(17):
pubmed: 36080493
Int J Mol Sci. 2021 Nov 26;22(23):
pubmed: 34884632
J Cell Physiol. 2020 May;235(5):4856-4864
pubmed: 31663131
J Hum Genet. 2021 Sep;66(9):937-945
pubmed: 34088973
Molecules. 2013 Sep 12;18(9):11219-40
pubmed: 24036512
Cell Mol Biol Lett. 2021 Oct 9;26(1):43
pubmed: 34627167
Cancer Immunol Immunother. 2021 Aug;70(8):2247-2259
pubmed: 33492448
Prostate. 2019 Jul;79(10):1125-1132
pubmed: 31045265
J Cell Biochem. 2019 Mar;120(3):4665-4674
pubmed: 30582227
Nucleic Acids Res. 2022 Jan 7;50(D1):D222-D230
pubmed: 34850920
Genes (Basel). 2020 Dec 23;12(1):
pubmed: 33374832
Crit Rev Oncol Hematol. 2018 Dec;132:1-8
pubmed: 30447913
Cancers (Basel). 2022 Mar 29;14(7):
pubmed: 35406504
Cancers (Basel). 2021 Apr 22;13(9):
pubmed: 33922197
Acta Biochim Biophys Sin (Shanghai). 2022 Dec 25;54(12):1775-1788
pubmed: 36789695
Curr Res Pharmacol Drug Discov. 2021 Jul 08;2:100034
pubmed: 34909665
Molecules. 2019 Jan 21;24(2):
pubmed: 30669618
J Nanobiotechnology. 2020 Jan 9;18(1):10
pubmed: 31918721
Cancer Metastasis Rev. 2021 Sep;40(3):925-948
pubmed: 33959850
Front Bioeng Biotechnol. 2020 Feb 14;8:81
pubmed: 32117949
Anticancer Agents Med Chem. 2021;21(3):355-364
pubmed: 32767958
Cancer Res. 2017 May 15;77(10):2746-2758
pubmed: 28363996
Clin Transl Oncol. 2019 Feb;21(2):126-144
pubmed: 29951892
Cancers (Basel). 2022 Apr 23;14(9):
pubmed: 35565237
Trends Cell Biol. 2021 Jan;31(1):3-5
pubmed: 33189493
Chin Med J (Engl). 2021 Mar 17;134(7):783-791
pubmed: 33734139
Int J Biol Sci. 2021 Aug 12;17(13):3456-3475
pubmed: 34512159
Drug Des Devel Ther. 2018 May 04;12:1119-1133
pubmed: 29765202
Eur J Pharmacol. 2021 May 15;899:174054
pubmed: 33771522
CA Cancer J Clin. 2020 May;70(3):145-164
pubmed: 32133645
J Clin Lab Anal. 2021 Aug;35(8):e23876
pubmed: 34132419
Front Oncol. 2021 Feb 05;10:610545
pubmed: 33614494
Mol Cancer. 2020 Nov 28;19(1):167
pubmed: 33246471
Transl Oncol. 2021 Oct;14(10):101174
pubmed: 34243011
Mol Ther Nucleic Acids. 2020 Jun 5;20:409-420
pubmed: 32244168
J Exp Clin Cancer Res. 2019 Feb 4;38(1):53
pubmed: 30717802
Mutat Res Rev Mutat Res. 2019 Jul - Sep;781:165-174
pubmed: 31416574
Gastroenterol Res Pract. 2020 Oct 28;2020:6478653
pubmed: 33193757
Cancer Cell Int. 2020 Sep 22;20:460
pubmed: 32973404
Oncol Lett. 2019 Oct;18(4):3994-4007
pubmed: 31565080