Modulation of Skin Cancer by the Stimulator of Interferon Genes.
BCC
SCC
STING
basal cell carcinoma
immunotherapy
interferons
melanoma
skin cancer
squamous cell carcinoma
Journal
Genes
ISSN: 2073-4425
Titre abrégé: Genes (Basel)
Pays: Switzerland
ID NLM: 101551097
Informations de publication
Date de publication:
13 Sep 2023
13 Sep 2023
Historique:
received:
16
08
2023
revised:
08
09
2023
accepted:
11
09
2023
medline:
28
9
2023
pubmed:
28
9
2023
entrez:
28
9
2023
Statut:
epublish
Résumé
Morbidity and mortality from skin cancer continue to rise domestically and globally, and melanoma and non-melanoma skin cancers are a topic of interest in the dermatology and oncology communities. In this review, we summarize the stimulator of interferon genes (STING) pathway, its specific role in the pathogenesis of DNA damage and skin cancer, and STING-specific therapies that may fight both melanoma and non-melanoma skin (NMSC) cancers. Furthermore, we discuss specific portions of the STING pathway that may be used in addition to previously used therapies to provide a synergistic effect in future oncology treatments and discuss the limitations of current STING-based therapies.
Identifiants
pubmed: 37761934
pii: genes14091794
doi: 10.3390/genes14091794
pmc: PMC10530941
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIAMS NIH HHS
ID : R01 AR071157
Pays : United States
Organisme : NIAMS NIH HHS
ID : 1R01AR071157-01A1
Pays : United States
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