Assessment of Apolipoprotein(a) Isoform Size Using Phenotypic and Genotypic Methods.
KIV 2
LPA gene
Lp(a)
apo(a)
apolipoprotein(a)
lipoprotein(a)
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
09 Sep 2023
09 Sep 2023
Historique:
received:
21
08
2023
revised:
03
09
2023
accepted:
06
09
2023
medline:
28
9
2023
pubmed:
28
9
2023
entrez:
28
9
2023
Statut:
epublish
Résumé
Apolipoprotein(a) (apo(a)) is the protein component that defines lipoprotein(a) (Lp(a)) particles and is encoded by the LPA gene. The apo(a) is extremely heterogeneous in size due to the copy number variations in the kringle-IV type 2 (KIV2) domains. In this review, we aim to discuss the role of genetics in establishing Lp(a) as a risk factor for coronary heart disease (CHD) by examining a series of molecular biology techniques aimed at identifying the best strategy for a possible application in clinical research and practice, according to the current gold standard.
Identifiants
pubmed: 37762189
pii: ijms241813886
doi: 10.3390/ijms241813886
pmc: PMC10531419
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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