Amyloid-Beta Co-Pathology Is a Major Determinant of the Elevated Plasma GFAP Values in Amyotrophic Lateral Sclerosis.
Alzheimer’s disease
GFAP
amyotrophic lateral sclerosis
biofluid biomarkers
co-pathology
neurodegeneration
neuropsychology
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
12 Sep 2023
12 Sep 2023
Historique:
received:
21
07
2023
revised:
29
08
2023
accepted:
09
09
2023
medline:
28
9
2023
pubmed:
28
9
2023
entrez:
28
9
2023
Statut:
epublish
Résumé
Recent studies reported increased plasma glial acidic fibrillary protein (GFAP) levels in amyotrophic lateral sclerosis (ALS) patients compared to controls. We expanded these findings in a larger cohort, including 156 ALS patients and 48 controls, and investigated the associations of plasma GFAP with clinical variables and other biofluid biomarkers. Plasma GFAP and Alzheimer's disease (AD) cerebrospinal fluid (CSF) biomarkers were assessed by the single molecule array and the Lumipulse platforms, respectively. In ALS patients, plasma GFAP was higher than in controls (
Identifiants
pubmed: 37762278
pii: ijms241813976
doi: 10.3390/ijms241813976
pmc: PMC10531493
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Ministero della Salute
ID : Ricerca Corrente
Organisme : #NextGenerationEU
ID : PE0000006
Références
Alzheimers Res Ther. 2022 Oct 12;14(1):153
pubmed: 36221099
Acta Psychiatr Scand. 1986 Jul;74(1):62-7
pubmed: 3766185
J Am Chem Soc. 2018 Dec 26;140(51):18132-18139
pubmed: 30495929
Brain. 2021 Dec 16;144(11):3505-3516
pubmed: 34259835
Alzheimers Res Ther. 2021 Oct 9;13(1):167
pubmed: 34627371
Ann Clin Transl Neurol. 2023 May;10(5):802-813
pubmed: 37000892
Amyotroph Lateral Scler Other Motor Neuron Disord. 2004 Mar;5(1):22-5
pubmed: 15204020
Nat Rev Neurol. 2022 Mar;18(3):158-172
pubmed: 35115728
Ann Clin Transl Neurol. 2018 Dec 14;6(2):263-273
pubmed: 30847359
J Neurol Neurosurg Psychiatry. 2016 Jan;87(1):12-20
pubmed: 26296871
Ann Neurol. 2022 Nov;92(5):807-818
pubmed: 35877814
Neurology. 2019 Sep 3;93(10):e984-e994
pubmed: 31409738
Alzheimers Dement. 2023 Apr;19(4):1403-1414
pubmed: 36152307
Brain. 2011 Sep;134(Pt 9):2456-77
pubmed: 21810890
Amyotroph Lateral Scler Frontotemporal Degener. 2017 May;18(3-4):153-174
pubmed: 28054827
Muscle Nerve. 2023 Jun;67(6):515-521
pubmed: 36928619
Amyotroph Lateral Scler Frontotemporal Degener. 2016 Oct - Nov;17(7-8):489-498
pubmed: 27219526
Neurology. 2020 Jul 7;95(1):e59-e69
pubmed: 32385188
Brain. 2023 Mar 1;146(3):1132-1140
pubmed: 36626935
Amyotroph Lateral Scler Other Motor Neuron Disord. 2000 Dec;1(5):293-9
pubmed: 11464847
Neurology. 2000 Dec 12;55(11):1621-6
pubmed: 11113214
Acta Neuropathol. 2004 Jun;107(6):515-22
pubmed: 15024584
JAMA Neurol. 2021 Dec 1;78(12):1471-1483
pubmed: 34661615
Amyotroph Lateral Scler. 2012 Feb;13(2):178-93
pubmed: 22214313
Clin Neurophysiol. 2008 Mar;119(3):497-503
pubmed: 18164242
Exp Neurol. 2013 Jan;239:133-8
pubmed: 23063604
Neurology. 2011 Mar 15;76(11):1006-14
pubmed: 21325651
Front Aging Neurosci. 2021 Oct 22;13:753242
pubmed: 34744694
Nat Med. 2023 Jul;29(7):1775-1781
pubmed: 37248300
Eur J Neurol. 2022 Jul;29(7):1930-1939
pubmed: 35263489
J Neurol Neurosurg Psychiatry. 2019 Jan;90(1):4-10
pubmed: 30224549
J Clin Neurosci. 2016 Apr;26:75-8
pubmed: 26602604
Neurol Sci. 2017 Jun;38(6):1059-1068
pubmed: 28332040
JAMA Neurol. 2022 Mar 01;79(3):228-243
pubmed: 35099509
J Neurol Neurosurg Psychiatry. 2023 Jun;94(6):428-435
pubmed: 37012065
Nat Rev Drug Discov. 2022 May;21(5):339-358
pubmed: 35173313
Mol Psychiatry. 2023 Apr 10;:
pubmed: 37037874
Trends Neurosci. 2015 Jun;38(6):364-74
pubmed: 25975510
Acta Neuropathol Commun. 2016 Mar 31;4:33
pubmed: 27036121
Neurology. 2016 Aug 2;87(5):539-47
pubmed: 27371494
J Neurol Neurosurg Psychiatry. 2011 Jul;82(7):740-6
pubmed: 21402743
Ann Clin Transl Neurol. 2023 Jan;10(1):118-129
pubmed: 36525477
J Neurol. 2021 Oct;268(10):3766-3776
pubmed: 33770234