Matricellular Proteins in the Homeostasis, Regeneration, and Aging of Skin.
basement membrane
epidermal stem cells
extracellular matrix
fibroblasts
matricellular proteins
skin aging
skin regeneration
wound healing
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
19 Sep 2023
19 Sep 2023
Historique:
received:
31
08
2023
revised:
13
09
2023
accepted:
15
09
2023
medline:
29
9
2023
pubmed:
28
9
2023
entrez:
28
9
2023
Statut:
epublish
Résumé
Matricellular proteins are secreted extracellular proteins that bear no primary structural functions but play crucial roles in tissue remodeling during development, homeostasis, and aging. Despite their low expression after birth, matricellular proteins within skin compartments support the structural function of many extracellular matrix proteins, such as collagens. In this review, we summarize the function of matricellular proteins in skin stem cell niches that influence stem cells' fate and self-renewal ability. In the epidermal stem cell niche, fibulin 7 promotes epidermal stem cells' heterogeneity and fitness into old age, and the transforming growth factor-β-induced protein ig-h3 (TGFBI)-enhances epidermal stem cell growth and wound healing. In the hair follicle stem cell niche, matricellular proteins such as periostin, tenascin C, SPARC, fibulin 1, CCN2, and R-Spondin 2 and 3 modulate stem cell activity during the hair cycle and may stabilize arrector pili muscle attachment to the hair follicle during piloerections (goosebumps). In skin wound healing, matricellular proteins are upregulated, and their functions have been examined in various gain-and-loss-of-function studies. However, much remains unknown concerning whether these proteins modulate skin stem cell behavior, plasticity, or cell-cell communications during wound healing and aging, leaving a new avenue for future studies.
Identifiants
pubmed: 37762584
pii: ijms241814274
doi: 10.3390/ijms241814274
pmc: PMC10531864
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : MEXT KAKENHI
ID : Grant-in-Aid for Scientific Research (C) (23K07737)
Organisme : Lydia O`leary Memorial PIAS Dermatological Foundation
ID : Elastin molecular research grant
Organisme : Japan Agency for Medical Research and Development
ID : JP21ek0109553h001
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