The Mechanotransduction Signaling Pathways in the Regulation of Osteogenesis.
bone formation
mechanical stimuli
mechanotransduction
microgravity
osteogenesis
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
20 Sep 2023
20 Sep 2023
Historique:
received:
28
08
2023
revised:
14
09
2023
accepted:
19
09
2023
medline:
29
9
2023
pubmed:
28
9
2023
entrez:
28
9
2023
Statut:
epublish
Résumé
Bones are constantly exposed to mechanical forces from both muscles and Earth's gravity to maintain bone homeostasis by stimulating bone formation. Mechanotransduction transforms external mechanical signals such as force, fluid flow shear, and gravity into intracellular responses to achieve force adaptation. However, the underlying molecular mechanisms on the conversion from mechanical signals into bone formation has not been completely defined yet. In the present review, we provide a comprehensive and systematic description of the mechanotransduction signaling pathways induced by mechanical stimuli during osteogenesis and address the different layers of interconnections between different signaling pathways. Further exploration of mechanotransduction would benefit patients with osteoporosis, including the aging population and postmenopausal women.
Identifiants
pubmed: 37762629
pii: ijms241814326
doi: 10.3390/ijms241814326
pmc: PMC10532275
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Natural Science Foundation of China
ID : 82072499, 32270610, and 31801094
Organisme : Beihang University
ID : YWF-21-BJ-J-T105
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