Nebulized Recombinant Tissue Plasminogen Activator (rt-PA) for Acute COVID-19-Induced Respiratory Failure: An Exploratory Proof-of-Concept Trial.

COVID-19 pandemic acute respiratory illness critical care fibrinolytics inhaled medication nebulization recombinant tissue plasminogen activator targeted therapy

Journal

Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588

Informations de publication

Date de publication:
08 Sep 2023
Historique:
received: 19 06 2023
revised: 31 08 2023
accepted: 04 09 2023
medline: 28 9 2023
pubmed: 28 9 2023
entrez: 28 9 2023
Statut: epublish

Résumé

Acute lung injury in COVID-19 results in diffuse alveolar damage with disruption of the alveolar-capillary barrier, coagulation activation, alveolar fibrin deposition and pulmonary capillary thrombi. Nebulized recombinant tissue plasminogen activator (rt-PA) has the potential to facilitate localized thrombolysis in the alveolar compartment and improve oxygenation. In this proof-of-concept safety study, adults with COVID-19-induced respiratory failure and a <300 mmHg PaO

Identifiants

pubmed: 37762789
pii: jcm12185848
doi: 10.3390/jcm12185848
pmc: PMC10531875
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : Royal Free Charity
ID : TF 35
Organisme : Boehringer Ingelheim (France)
ID : Drug suppport

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Auteurs

Pratima Chowdary (P)

Katharine Dormandy Haemophilia and Thrombosis Centre, Royal Free London NHS Foundation Trust, London NW3 2QG, UK.
Cancer Institute, University College London, London WC1E 6DD, UK.

Banwari Agarwal (B)

Department of Intensive Care and Anaesthesia, Royal Free London NHS Foundation Trust, London NW3 2QG, UK.

Maria Rita Peralta (MR)

Katharine Dormandy Haemophilia and Thrombosis Centre, Royal Free London NHS Foundation Trust, London NW3 2QG, UK.
Cancer Institute, University College London, London WC1E 6DD, UK.

Sanjay Bhagani (S)

Department of Infectious Diseases, Royal Free London NHS Foundation Trust, London NW3 2QG, UK.

Simon Lee (S)

Department of Infectious Diseases, Royal Free London NHS Foundation Trust, London NW3 2QG, UK.

James Goldring (J)

Respiratory Medicine, Royal Free London NHS Foundation Trust, London NW1 2BU, UK.

Marc Lipman (M)

Respiratory Medicine, Royal Free London NHS Foundation Trust, London NW1 2BU, UK.
UCL Respiratory, University College London, London WC1E 6JF, UK.

Emal Waqif (E)

Katharine Dormandy Haemophilia and Thrombosis Centre, Royal Free London NHS Foundation Trust, London NW3 2QG, UK.

Mark Phillips (M)

Katharine Dormandy Haemophilia and Thrombosis Centre, Royal Free London NHS Foundation Trust, London NW3 2QG, UK.
Cancer Institute, University College London, London WC1E 6DD, UK.

Helen Philippou (H)

Discovery and Translational Science Department, Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds LS2 9JT, UK.

Jonathan H Foley (JH)

Freeline Therapeutics, London SG1 2BP, UK.

Nicola J Mutch (NJ)

Aberdeen Cardiovascular & Diabetes Centre, School of Medicine, Medical Sciences & Nutrition, Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, UK.

Robert A S Ariëns (RAS)

Discovery and Translational Science Department, Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds LS2 9JT, UK.

Kathleen A Stringer (KA)

Department of Clinical Pharmacy, College of Pharmacy University of Michigan, Ann Arbor, MI 48109, USA.
Division of Pulmonary and Critical Care Medicine, School of Medicine, University of Michigan, Ann Arbor, MI 48109, USA.

Federico Ricciardi (F)

Department of Statistical Science, University College London, London WC1E 6BT, UK.

Marie Watissée (M)

WStats Limited, Winchester SO23 8GH, UK.

Derralynn Hughes (D)

Cancer Institute, University College London, London WC1E 6DD, UK.

Amit Nathwani (A)

Katharine Dormandy Haemophilia and Thrombosis Centre, Royal Free London NHS Foundation Trust, London NW3 2QG, UK.
Cancer Institute, University College London, London WC1E 6DD, UK.

Anne Riddell (A)

Katharine Dormandy Haemophilia and Thrombosis Centre, Royal Free London NHS Foundation Trust, London NW3 2QG, UK.
Haemophilia & Thrombosis Laboratory (Health Services Laboratories), Royal Free Hospital, London WC1H 9AX, UK.

David Patch (D)

Department of Hepatology, Royal Free London NHS Foundation Trust, London NW3 2QG, UK.

Jim Buckley (J)

Department of Intensive Care and Anaesthesia, Royal Free London NHS Foundation Trust, London NW3 2QG, UK.

Mark De Neef (M)

Department of Intensive Care and Anaesthesia, Royal Free London NHS Foundation Trust, London NW3 2QG, UK.

Rahul Dimber (R)

Department of Intensive Care and Anaesthesia, Royal Free London NHS Foundation Trust, London NW3 2QG, UK.

Cecilia Diaz-Garcia (C)

Katharine Dormandy Haemophilia and Thrombosis Centre, Royal Free London NHS Foundation Trust, London NW3 2QG, UK.

Honey Patel (H)

Katharine Dormandy Haemophilia and Thrombosis Centre, Royal Free London NHS Foundation Trust, London NW3 2QG, UK.

Aarti Nandani (A)

Clinical Trials Pharmacy, Royal Free London NHS Foundation Trust, London NW3 2QG, UK.

Upuli Dissanayake (U)

Katharine Dormandy Haemophilia and Thrombosis Centre, Royal Free London NHS Foundation Trust, London NW3 2QG, UK.

Nick Chadwick (N)

Katharine Dormandy Haemophilia and Thrombosis Centre, Royal Free London NHS Foundation Trust, London NW3 2QG, UK.

Ahmed A A M M Alkhatip (AAAMM)

Department of Anaesthesia, Birmingham Children's Hospital, Birmingham B4 6NH, UK.
Department of Anaesthesia, Faculty of Medicine, Beni-Suef University Hospital, Beni-Suef University, Beni-Suef 2721562, Egypt.

Peter Watkinson (P)

NIHR Biomedical Research Centre Oxford, Oxford University Hospitals NHS Trust, University of Oxford, Oxford OX3 9DU, UK.

Eamon Raith (E)

Bloomsbury Institute for Intensive Care Medicine, Department of Experimental and Translational Medicine, University College London, London WC1E 6JF, UK.
Discipline of Acute Care Medicine, School of Medicine, The University of Adelaide, Adelaide, SA 5005, Australia.

Suveer Singh (S)

Department of Respiratory and Critical Care Medicine, Chelsea & Westminster Hospital, London SW10 9NH, UK.
Department of Adult Intensive Care, Royal Brompton Hospital, London SW3 6NP, UK.
Department of Surgery and Cancer, Imperial College London, London SW7 2AZ, UK.

Tony Wolff (T)

Department of Intensive Care and Anaesthesia, Royal Free London NHS Foundation Trust, London NW3 2QG, UK.

Rajeev Jha (R)

Department of Intensive Care and Anaesthesia, Royal Free London NHS Foundation Trust, London NW3 2QG, UK.

Simon E Brill (SE)

UCL Respiratory, University College London, London WC1E 6JF, UK.

Ameet Bakhai (A)

Department of Intensive Care and Anaesthesia, Royal Free London NHS Foundation Trust, London NW3 2QG, UK.
Department of Cardiology, Royal Free London NHS Foundation Trust, London NW3 2PS, UK.

Alison Evans (A)

University College London (UCL)/University College London Hospitals NHS Trust (UCLH) Joint Research Office, London WC1E 6BT, UK.

Farhat Gilani (F)

University College London (UCL)/University College London Hospitals NHS Trust (UCLH) Joint Research Office, London WC1E 6BT, UK.

Keith Gomez (K)

Katharine Dormandy Haemophilia and Thrombosis Centre, Royal Free London NHS Foundation Trust, London NW3 2QG, UK.
Cancer Institute, University College London, London WC1E 6DD, UK.

Classifications MeSH