mRNA Abundance of Neurogenic Factors Correlates with Hearing Capacity in Auditory Brainstem Nuclei of the Rat.
auditory pathway
cochlear nucleus
neurogenesis
real-time PCR
Journal
Life (Basel, Switzerland)
ISSN: 2075-1729
Titre abrégé: Life (Basel)
Pays: Switzerland
ID NLM: 101580444
Informations de publication
Date de publication:
02 Sep 2023
02 Sep 2023
Historique:
received:
07
08
2023
revised:
30
08
2023
accepted:
31
08
2023
medline:
28
9
2023
pubmed:
28
9
2023
entrez:
28
9
2023
Statut:
epublish
Résumé
Neural stem cells (NSCs) have previously been described up to the adult stage in the rat cochlear nucleus (CN). A decreasing neurogenic potential was observed with critical changes around hearing onset. A better understanding of molecular factors affecting NSCs and neurogenesis is of interest as they represent potential targets to treat the cause of neurologically based hearing disorders. The role of genes affecting NSC development and neurogenesis in CN over time on hearing capacity has remained unclear. This study investigated the mRNA abundance of genes influencing NSCs and neurogenesis in rats' CN over time. The CN of rats on postnatal days 6, 12, and 24 were examined. Real-time quantitative polymerase chain reaction arrays were used to compare mRNA levels of 84 genes relevant to NSCs and neurogenesis. Age- and hearing-specific patterns of changes in mRNA abundance of neurogenically relevant genes were detected in the rat CN. Additionally, crucial neurogenic factors with significant and relevant influence on neurogenesis were identified. The results of this work should contribute to a better understanding of the molecular mechanisms underlying the neurogenesis of the auditory pathway.
Identifiants
pubmed: 37763262
pii: life13091858
doi: 10.3390/life13091858
pmc: PMC10532994
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : "Interdisciplinary Center for Clinical Research Wuerzburg", IZKF Wuerzburg
ID : #Z-2/CSP-4
Organisme : "Interdisciplinary Center for Clinical Research Wuerzburg", IZKF Wuerzburg
ID : #Z-2/89
Organisme : "Interdisciplinary Center for Clinical Research Wuerzburg", IZKF Wuerzburg
ID : #Z3BC/05
Organisme : Deutsche Forschungsgemeinschaft
ID : DFG VO 2138/7-1, 469177153
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