A Multi-Layer Breast Cancer Model to Study the Synergistic Effect of Photochemotherapy.
breast cancer
cancer-on-a-chip
meso-tetraphenylporphyrin
multilayered cell model
sequential photochemotherapy
three-dimensional (3D) cell culture
Journal
Micromachines
ISSN: 2072-666X
Titre abrégé: Micromachines (Basel)
Pays: Switzerland
ID NLM: 101640903
Informations de publication
Date de publication:
21 Sep 2023
21 Sep 2023
Historique:
received:
24
08
2023
revised:
15
09
2023
accepted:
18
09
2023
medline:
28
9
2023
pubmed:
28
9
2023
entrez:
28
9
2023
Statut:
epublish
Résumé
Breast cancer is one of the most common cancers among women. The development of new and effective therapeutic approaches in the treatment of breast cancer is an important challenge in modern oncology. Two-dimensional (2D) cell cultures are most often used in the study of compounds with potential anti-tumor nature. However, it is necessary to develop advanced three-dimensional (3D) cell models that can, to some extent, reflect the physiological conditions. The use of miniature cancer-on-a-chip microfluidic systems can help to mimic the complex cancer microenvironment. In this report, we developed a 3D breast cancer model in the form of a cell multilayer, composed of stromal cells (HMF) and breast cancer parenchyma (MCF-7). The developed cell model was successfully used to analyze the effectiveness of combined sequential photochemotherapy, based on doxorubicin and
Identifiants
pubmed: 37763969
pii: mi14091806
doi: 10.3390/mi14091806
pmc: PMC10535669
pii:
doi:
Types de publication
Journal Article
Langues
eng
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