Stimulation of Hemolysis and Eryptosis by α-Mangostin through Rac1 GTPase and Oxidative Injury in Human Red Blood Cells.
anticancer
eryptosis
hemolysis
mangostin
oxidative stress
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
07 Sep 2023
07 Sep 2023
Historique:
received:
28
07
2023
revised:
02
09
2023
accepted:
04
09
2023
medline:
28
9
2023
pubmed:
28
9
2023
entrez:
28
9
2023
Statut:
epublish
Résumé
Chemotherapy-related anemia is prevalent in up to 75% of patients, which may arise due to hemolysis and eryptosis. Alpha-mangostin (α-MG) is a polyphenolic xanthonoid found in the mangosteen tree ( RBCs were exposed to 1-40 μM of α-MG for 24 h at 37 °C. Hemolysis and related markers were measured using colorimetric assays, eryptotic cells were identified through Annexin-V-FITC, Ca α-MG at 10-40 μM caused dose-dependent hemolysis with concurrent significant elevation in K α-MG possesses hemolytic and eryptotic activities mediated through Ca
Sections du résumé
BACKGROUND
BACKGROUND
Chemotherapy-related anemia is prevalent in up to 75% of patients, which may arise due to hemolysis and eryptosis. Alpha-mangostin (α-MG) is a polyphenolic xanthonoid found in the mangosteen tree (
METHODS
METHODS
RBCs were exposed to 1-40 μM of α-MG for 24 h at 37 °C. Hemolysis and related markers were measured using colorimetric assays, eryptotic cells were identified through Annexin-V-FITC, Ca
RESULTS
RESULTS
α-MG at 10-40 μM caused dose-dependent hemolysis with concurrent significant elevation in K
CONCLUSIONS
CONCLUSIONS
α-MG possesses hemolytic and eryptotic activities mediated through Ca
Identifiants
pubmed: 37764276
pii: molecules28186495
doi: 10.3390/molecules28186495
pmc: PMC10535552
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Deputyship for Research and Innovation, Ministry of Education, Saudi Arabia
ID : IFKSUDR-H115
Références
Clin Hemorheol Microcirc. 2001;25(3-4):153-63
pubmed: 11847418
Mol Cancer. 2014 Jun 03;13:138
pubmed: 24894151
PLoS One. 2015 Jun 05;10(6):e0129337
pubmed: 26047511
Saudi J Biol Sci. 2018 Sep;25(6):1090-1095
pubmed: 30174507
Bioorg Med Chem Lett. 2015 Feb 15;25(4):826-9
pubmed: 25592715
Chem Phys Lipids. 2002 Oct;119(1-2):33-9
pubmed: 12270671
World J Gastroenterol. 2011 Apr 28;17(16):2086-95
pubmed: 21547127
Chem Biol Interact. 2015 Oct 5;240:240-8
pubmed: 26343955
Front Physiol. 2014 Jan 30;5:9
pubmed: 24523696
Phytother Res. 2023 Aug;37(8):3394-3407
pubmed: 37012651
Front Cell Dev Biol. 2020 Jul 08;8:597
pubmed: 32733893
Basic Clin Pharmacol Toxicol. 2009 Feb;104(2):138-44
pubmed: 19143753
Eur Biophys J. 2004 Aug;33(5):448-53
pubmed: 14714154
Int J Mol Sci. 2023 Mar 07;24(6):
pubmed: 36982153
Int J Biochem Cell Biol. 2012 Aug;44(8):1236-43
pubmed: 22561748
Nucleic Acids Res. 2015 Jan;43(Database issue):D447-52
pubmed: 25352553
Bioorg Med Chem Lett. 2016 May 15;26(10):2503-2506
pubmed: 27040657
Cell Physiol Biochem. 2019;53(6):933-947
pubmed: 31805226
Front Nutr. 2022 Jan 28;8:714463
pubmed: 35155508
Sci Rep. 2016 Feb 18;6:21018
pubmed: 26888416
Mol Cell Biochem. 2018 Mar;440(1-2):105-113
pubmed: 28822022
Biochim Biophys Acta. 1997 Sep 4;1328(2):281-9
pubmed: 9315624
Cell Physiol Biochem. 2016;39(5):1977-2000
pubmed: 27771701
Ann Hematol. 2009 Aug;88(8):721-6
pubmed: 19184015
Blood. 2013 Mar 14;121(11):2099-107
pubmed: 23349388
J BUON. 2020 Sep-Oct;25(5):2293-2300
pubmed: 33277848
Biomed Res Int. 2014;2014:546353
pubmed: 24812621
Front Cell Infect Microbiol. 2018 Nov 30;8:419
pubmed: 30560094
Expert Opin Ther Pat. 2018 May;28(5):415-427
pubmed: 29558225
J Natl Cancer Inst. 1999 Oct 6;91(19):1616-34
pubmed: 10511589
Biosensors (Basel). 2023 May 31;13(6):
pubmed: 37366964
Clin Hemorheol Microcirc. 2018;69(4):545-550
pubmed: 29710698
Indian J Clin Biochem. 2018 Oct;33(4):445-449
pubmed: 30319191
Biomed Pharmacother. 2017 Aug;92:672-680
pubmed: 28582759
Antioxidants (Basel). 2023 Jul 21;12(7):
pubmed: 37508006
Int J Mol Sci. 2020 Jun 24;21(12):
pubmed: 32599721
Hum Cell. 2020 Apr;33(2):347-355
pubmed: 32078151
Int J Mol Sci. 2023 Feb 02;24(3):
pubmed: 36769243
Biology (Basel). 2020 Jan 20;9(1):
pubmed: 31968627
Front Pharmacol. 2021 Aug 30;12:739658
pubmed: 34539418
Int J Cancer. 2017 Oct 15;141(8):1522-1528
pubmed: 28542880
Xenobiotica. 2023 Aug 21;:1-9
pubmed: 37590011
Mol Cell Biochem. 2011 Nov;357(1-2):171-9
pubmed: 21625956
Biochem Pharmacol. 2003 Aug 15;66(4):605-12
pubmed: 12906925
Drug Des Devel Ther. 2023 Feb 23;17:563-577
pubmed: 36860800
Cell Death Dis. 2020 Jan 24;11(1):63
pubmed: 31980595