The Circadian Nobiletin-ROR Axis Suppresses Adipogenic Differentiation and IκBα/NF-κB Signaling in Adipocytes.
3T3-L1
IκBα/NF-κB
Nobiletin
adipocytes
circadian clock
lipid
obesity
retinoic acid receptor-related orphan receptors (RORs)
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
09 Sep 2023
09 Sep 2023
Historique:
received:
18
08
2023
revised:
07
09
2023
accepted:
08
09
2023
medline:
28
9
2023
pubmed:
28
9
2023
entrez:
28
9
2023
Statut:
epublish
Résumé
Obesity is a known risk factor for metabolic diseases and is often associated with chronic inflammation in adipose tissue. We previously identified the polyethoxylated flavonoid Nobiletin (NOB) as a circadian clock modulator that directly binds to and activates the ROR receptors in the core oscillator, markedly improving metabolic fitness in obese mice. Here, we show that NOB enhanced the oscillation of core clock genes in differentiated 3T3-L1 adipocytes, including ROR target genes such as
Identifiants
pubmed: 37764703
pii: nu15183919
doi: 10.3390/nu15183919
pmc: PMC10537147
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIA NIH HHS
ID : R01 AG065984
Pays : United States
Organisme : NIA NIH HHS
ID : R56 AG063746
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM145232
Pays : United States
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