Erythritol Can Inhibit the Expression of Senescence Molecules in Mouse Gingival Tissues and Human Gingival Fibroblasts.
cellular senescence
gingiva
oral aging
senolytic drugs
sugar alcohol
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
19 Sep 2023
19 Sep 2023
Historique:
received:
22
08
2023
revised:
08
09
2023
accepted:
12
09
2023
medline:
29
9
2023
pubmed:
28
9
2023
entrez:
28
9
2023
Statut:
epublish
Résumé
Oral aging causes conditions including periodontal disease. We investigated how the sugar alcohol erythritol, which has anti-caries effects, impacts aging periodontal tissues and gingival fibroblasts in mice and humans in vivo and in vitro. Mice were classified into three groups: control groups of six-week-old (YC) and eighteen-month-old mice (AC) and a group receiving 5%
Identifiants
pubmed: 37764833
pii: nu15184050
doi: 10.3390/nu15184050
pmc: PMC10537281
pii:
doi:
Substances chimiques
Erythritol
RA96B954X6
Tumor Necrosis Factor-alpha
0
Cariostatic Agents
0
Hydrogen Peroxide
BBX060AN9V
NF-kappa B
0
RNA, Messenger
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Japan Society for the Promotion of Science
ID : RPD No. 21J40002, 22KJ3207
Organisme : the National Geriatrics and Gerontology of Japan
ID : Grant No. 20-13, 21-6
Organisme : Hokuto Foundation for Bioscience
ID : R1 No. 19
Organisme : KAKENHI
ID : Grant No. 22K10112, 20H03904 and 23H03122
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