On-Demand Release of Anti-Infective Silver from a Novel Implant Coating Using High-Energy Focused Shock Waves.
anti-infective silver
extracorporeal shock waves
implant coating
implant-related infection
Journal
Pharmaceutics
ISSN: 1999-4923
Titre abrégé: Pharmaceutics
Pays: Switzerland
ID NLM: 101534003
Informations de publication
Date de publication:
22 Aug 2023
22 Aug 2023
Historique:
received:
05
08
2023
revised:
16
08
2023
accepted:
18
08
2023
medline:
28
9
2023
pubmed:
28
9
2023
entrez:
28
9
2023
Statut:
epublish
Résumé
Implant-related infections are a significant concern in orthopedic surgery. A novel anti-infective implant coating made of bioresorbable polymer with silver nitrate was developed. A controlled release of silver ions into the vicinity of the prosthesis can be triggered on-demand by extracorporeal shock waves to effectively combat all clinically relevant microorganisms. Microscopy techniques were used to examine the effects of shock wave application on coated titanium discs. Cytotoxicity was measured using a fibroblast proliferation assay. The anti-infective effect was assessed by monitoring the growth curves of three bacterial strains and by conventional culture. Microscopic analysis confirmed surface disruption of the coatings, with a complete release of silver in the focus area after shock wave application. Spectrometry detected an increase in silver concentration in the surrounding of the discs that surpassed the minimum inhibitory concentration (MIC) for both
Identifiants
pubmed: 37765150
pii: pharmaceutics15092179
doi: 10.3390/pharmaceutics15092179
pmc: PMC10537269
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Else-Kröner-Fresenius Stiftung
ID : 2021_EKEA.129
Organisme : IMF Faculty program of the University of Muenster
ID : I-SC122008
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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