Karaya/Gellan-Gum-Based Bilayer Films Containing 3,3'-Diindolylmethane-Loaded Nanocapsules: A Promising Alternative to Melanoma Topical Treatment.
cutaneous delivery
indole-3-carbinol
nanocarriers
skin cancer
solid formulations
Journal
Pharmaceutics
ISSN: 1999-4923
Titre abrégé: Pharmaceutics
Pays: Switzerland
ID NLM: 101534003
Informations de publication
Date de publication:
29 Aug 2023
29 Aug 2023
Historique:
received:
28
07
2023
revised:
26
08
2023
accepted:
28
08
2023
medline:
28
9
2023
pubmed:
28
9
2023
entrez:
28
9
2023
Statut:
epublish
Résumé
This study aimed to incorporate nanocapsules containing 3,3'-diindolylmethane (DIM) with antitumor activity into a bilayer film of karaya and gellan gums for use in topical melanoma therapy. Nanocarriers and films were prepared by interfacial deposition of the preformed polymer and solvent casting methods, respectively. Incorporating DIM into nanocapsules increased its antitumor potential against human melanoma cells (A-375) (IC
Identifiants
pubmed: 37765203
pii: pharmaceutics15092234
doi: 10.3390/pharmaceutics15092234
pmc: PMC10538082
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul
ID : 21/2551-0002062-8
Déclaration de conflit d'intérêts
The authors declare no conflicts of interest.
Références
Breast Cancer Res Treat. 2017 Aug;165(1):97-107
pubmed: 28560655
Carbohydr Polym. 2015 Oct 5;130:183-90
pubmed: 26076615
Food Chem. 2021 May 30;345:128859
pubmed: 33333356
Int J Pharm. 2011 Oct 10;418(1):6-12
pubmed: 21458553
Eur J Pharm Sci. 2020 Aug 1;151:105379
pubmed: 32473199
Angew Chem Int Ed Engl. 2005 Dec 2;44(47):7686-708
pubmed: 16283684
Dermatol Ther. 2020 Nov;33(6):e14165
pubmed: 32772481
Food Chem. 2013 Aug 15;139(1-4):224-30
pubmed: 23561099
Mater Sci Eng C Mater Biol Appl. 2021 Feb;119:111624
pubmed: 33321666
Colloids Surf B Biointerfaces. 2016 Aug 1;144:65-72
pubmed: 27070053
Int J Pharm. 2019 Jan 30;555:49-62
pubmed: 30448309
Int J Biol Macromol. 2020 Dec 1;164:606-615
pubmed: 32652149
Drug Dev Ind Pharm. 2017 Jun;43(6):917-924
pubmed: 28076697
Int J Biol Macromol. 2020 Apr 1;148:248-257
pubmed: 31954791
Behav Brain Res. 2020 Jul 15;390:112696
pubmed: 32417280
Ann Surg Oncol. 2020 Jan;27(1):35-42
pubmed: 31471842
Drug Deliv Transl Res. 2020 Aug;10(4):1032-1043
pubmed: 32100268
J Nanosci Nanotechnol. 2016 Feb;16(2):1331-8
pubmed: 27433583
J Immunol Methods. 1983 Dec 16;65(1-2):55-63
pubmed: 6606682
Pharmaceutics. 2022 Oct 31;14(11):
pubmed: 36365170
J Photochem Photobiol B. 2017 May;170:25-32
pubmed: 28365493
Colloids Surf B Biointerfaces. 2019 Feb 1;174:582-586
pubmed: 30502670
Eur J Pharm Sci. 2012 May 12;46(1-2):8-16
pubmed: 22342559
Mater Sci Eng C Mater Biol Appl. 2021 Jan;120:111681
pubmed: 33545843
Front Immunol. 2017 Dec 08;8:1617
pubmed: 29276510
Free Radic Biol Med. 1999 May;26(9-10):1231-7
pubmed: 10381194
Mater Sci Eng C Mater Biol Appl. 2019 Oct;103:109770
pubmed: 31349525
Phytomedicine. 2018 Jan 15;39:100-110
pubmed: 29433671
Oncotarget. 2017 Jun 27;8(39):65339-65358
pubmed: 29029435
Biomed Res Int. 2014;2014:641590
pubmed: 24524083
Sci Rep. 2017 Nov 28;7(1):16517
pubmed: 29184162
Int J Oncol. 2018 Apr;52(4):1071-1080
pubmed: 29532857
Eur J Pharm Sci. 2021 May 1;160:105769
pubmed: 33610737
Carbohydr Polym. 2022 Feb 15;278:118958
pubmed: 34973774
J Med Food. 2020 Dec;23(12):1248-1258
pubmed: 33237846
J Pharm Sci. 2019 Oct;108(10):3396-3407
pubmed: 31201905
Photochem Photobiol. 2017 Jul;93(4):956-974
pubmed: 28063168
Int J Pharm. 2021 Nov 20;609:121144
pubmed: 34600055
Eur J Pharm Biopharm. 2011 Feb;77(2):187-99
pubmed: 21130875
AAPS PharmSciTech. 2017 Nov;18(8):3236-3246
pubmed: 28577126
Food Chem. 2014 Sep 15;159:529-35
pubmed: 24767092
Am J Transl Res. 2016 Jan 15;8(1):166-76
pubmed: 27069550
Pharm Dev Technol. 2018 Apr;23(4):400-406
pubmed: 28521578
Eur J Pharm Sci. 2018 May 30;117:245-254
pubmed: 29499350
AAPS PharmSciTech. 2019 Jan 7;20(2):49
pubmed: 30617655
J Nanosci Nanotechnol. 2015 Jan;15(1):875-9
pubmed: 26328452
Int J Mol Sci. 2019 Aug 12;20(16):
pubmed: 31408980
Nanomaterials (Basel). 2020 Apr 28;10(5):
pubmed: 32354008
Int J Pharm. 2022 Oct 15;626:122166
pubmed: 36075522
Invest New Drugs. 2020 Jun;38(3):662-674
pubmed: 31264068
J Am Acad Dermatol. 2019 Jan;80(1):208-250
pubmed: 30392755
Mater Sci Eng C Mater Biol Appl. 2018 Jan 1;82:317-322
pubmed: 29025664
Biomed Res Int. 2017;2017:2037341
pubmed: 28812011
Int J Biol Macromol. 2018 Oct 15;118(Pt A):584-587
pubmed: 29959005
Mater Sci Eng C Mater Biol Appl. 2019 Mar;96:205-217
pubmed: 30606527
Eur J Pharm Biopharm. 2005 Jan;59(1):189-96
pubmed: 15567317
Int J Nanomedicine. 2019 Dec 31;14:10165-10178
pubmed: 32021159
Int J Pharm. 2020 Sep 25;587:119626
pubmed: 32659404
CA Cancer J Clin. 2017 Nov;67(6):472-492
pubmed: 29028110
Colloids Surf B Biointerfaces. 2019 Jun 1;178:488-499
pubmed: 30925372
Int J Pharm. 2014 May 15;466(1-2):328-40
pubmed: 24657577
Mater Sci Eng C Mater Biol Appl. 2018 Oct 1;91:1-9
pubmed: 30033235
Carbohydr Polym. 2021 Apr 15;258:117687
pubmed: 33593560
Eur J Pharm Sci. 2020 Oct 1;153:105500
pubmed: 32738295
Int J Biol Macromol. 2021 Jan 1;166:483-495
pubmed: 33130262
Saudi Pharm J. 2016 Sep;24(5):537-546
pubmed: 27752225
Exp Ther Med. 2014 Jun;7(6):1635-1638
pubmed: 24926357
AAPS PharmSciTech. 2020 Oct 25;21(8):295
pubmed: 33099708
Antioxid Redox Signal. 2013 Jul 10;19(2):139-50
pubmed: 23391445
Biomed Res Int. 2015;2015:841817
pubmed: 26078967
J Control Release. 2020 Nov 10;327:477-499
pubmed: 32853730
Colloids Surf B Biointerfaces. 2015 Jun 1;130:272-7
pubmed: 25935266
Adv Drug Deliv Rev. 2020 Jan 1;153:109-136
pubmed: 32113956
Drug Deliv Transl Res. 2020 Dec;10(6):1829-1840
pubmed: 32562254
Indian Dermatol Online J. 2013 Oct;4(4):267-72
pubmed: 24350003
ACS Appl Bio Mater. 2022 Jun 20;5(6):2880-2893
pubmed: 35583459