Antifungal Activity of Chitosan/Poly(Ethylene Oxide) Blend Electrospun Polymeric Fiber Mat Doped with Metallic Silver Nanoparticles.
AgNPs
LSPR
antifungal
blend electrospun mat
chitosan
dip-coating
electrospinning
polyethylene oxide
Journal
Polymers
ISSN: 2073-4360
Titre abrégé: Polymers (Basel)
Pays: Switzerland
ID NLM: 101545357
Informations de publication
Date de publication:
08 Sep 2023
08 Sep 2023
Historique:
received:
08
08
2023
revised:
29
08
2023
accepted:
05
09
2023
medline:
28
9
2023
pubmed:
28
9
2023
entrez:
28
9
2023
Statut:
epublish
Résumé
In this work, the implementation of advanced functional coatings based on the combination of two compatible nanofabrication techniques such as electrospinning and dip-coating technology have been successfully obtained for the design of antifungal surfaces. In a first step, uniform and beadless electrospun nanofibers of both polyethylene oxide (PEO) and polyethylene (PEO)/chitosan (CS) blend samples have been obtained. In a second step, the dip-coating process has been gradually performed in order to ensure an adequate distribution of silver nanoparticles (AgNPs) within the electrospun polymeric matrix (PEO/CS/AgNPs) by using a chemical reduction synthetic process, denoted as in situ synthesis (ISS). Scanning electron microscopy (SEM) has been used to evaluate the surface morphology of the samples, showing an evolution in average fiber diameter from 157 ± 43 nm (PEO), 124 ± 36 nm (PEO/CS) and 330 ± 106 nm (PEO/CS/AgNPs). Atomic force microscopy (AFM) has been used to evaluate the roughness profile of the samples, indicating that the ISS process induced a smooth roughness surface because a change in the average roughness Ra from 84.5 nm (PEO/CS) up to 38.9 nm (PEO/CS/AgNPs) was observed. The presence of AgNPs within the electrospun fiber mat has been corroborated by UV-Vis spectroscopy thanks to their characteristic optical properties (orange film coloration) associated to the Localized Surface Plasmon Resonance (LSPR) phenomenon by showing an intense absorption band in the visible region at 436 nm. Energy dispersive X-ray (EDX) profile also indicates the existence of a peak located at 3 keV associated to silver. In addition, after doping the electrospun nanofibers with AgNPs, an important change in the wettability with an intrinsic hydrophobic behavior was observed by showing an evolution in the water contact angle value from 23.4° ± 1.3 (PEO/CS) up to 97.7° ± 5.3 (PEO/CS/AgNPs). The evaluation of the antifungal activity of the nanofibrous mats against
Identifiants
pubmed: 37765554
pii: polym15183700
doi: 10.3390/polym15183700
pmc: PMC10536667
pii:
doi:
Types de publication
Journal Article
Langues
eng
Références
Arch Oral Biol. 2009 Jun;54(6):595-601
pubmed: 19375069
Nanomedicine. 2016 Jul;12(5):1357-64
pubmed: 26970025
Langmuir. 2006 Jan 3;22(1):32-41
pubmed: 16378396
Carbohydr Polym. 2016 Apr 20;140:287-98
pubmed: 26876856
Int J Biol Macromol. 2023 Apr 30;235:123704
pubmed: 36801282
Nanoscale Res Lett. 2014 Jun 13;9(1):301
pubmed: 24982607
AMB Express. 2013 Jul 06;3(1):37
pubmed: 23829873
J Food Sci. 2013 Jun;78(6):N926-35
pubmed: 23627787
Polymers (Basel). 2020 Sep 14;12(9):
pubmed: 32937791
Appl Environ Microbiol. 1999 Aug;65(8):3413-7
pubmed: 10427028
Biomacromolecules. 2003 Nov-Dec;4(6):1457-65
pubmed: 14606868
J Am Chem Soc. 2006 Aug 2;128(30):9798-808
pubmed: 16866536
Biochim Biophys Acta. 2015 Feb;1850(2):299-306
pubmed: 25450183
Eukaryot Cell. 2007 May;6(5):855-67
pubmed: 17400891
Carbohydr Polym. 2019 Mar 1;207:588-600
pubmed: 30600043
Nanoscale. 2014 Aug 21;6(16):9477-93
pubmed: 25000536
Biomaterials. 2005 Nov;26(31):6176-84
pubmed: 15885770
Polymers (Basel). 2021 Nov 28;13(23):
pubmed: 34883667
Nanoscale Res Lett. 2013 Feb 22;8(1):101
pubmed: 23432942
Int J Biomater. 2012;2012:632698
pubmed: 22829829
Science. 2007 Dec 7;318(5856):1618-22
pubmed: 18063796
Nanomedicine. 2007 Mar;3(1):95-101
pubmed: 17379174
Nanomaterials (Basel). 2017 Dec 27;8(1):
pubmed: 29280980
Carbohydr Polym. 2014 Jan 16;100:166-78
pubmed: 24188851
Sci Rep. 2022 Oct 27;12(1):18046
pubmed: 36302952
Nanomaterials (Basel). 2020 Feb 09;10(2):
pubmed: 32050443
J Biomater Sci Polym Ed. 2004;15(6):797-811
pubmed: 15255527
Int J Mol Sci. 2018 Jan 30;19(2):
pubmed: 29385727
Mater Sci Eng C Mater Biol Appl. 2017 Jul 1;76:1413-1423
pubmed: 28482508
ACS Nano. 2009 Feb 24;3(2):279-90
pubmed: 19236062
Appl Environ Microbiol. 2008 Jun;74(12):3764-73
pubmed: 18456858
Angew Chem Int Ed Engl. 2009;48(29):5326-9
pubmed: 19526478
J Environ Qual. 2010 Nov-Dec;39(6):1875-82
pubmed: 21284285
Food Sci Nutr. 2021 Sep 23;9(11):6353-6361
pubmed: 34760265
Nanoscale Res Lett. 2011 Apr 07;6(1):305
pubmed: 21711825
Carbohydr Res. 2010 Nov 2;345(16):2374-80
pubmed: 20851381
Chem Soc Rev. 2012 Jul 7;41(13):4708-35
pubmed: 22618026
Biomacromolecules. 2012 Feb 13;13(2):412-21
pubmed: 22229633
Polymers (Basel). 2021 Jun 20;13(12):
pubmed: 34203003
Int J Mol Sci. 2019 Nov 24;20(23):
pubmed: 31771245
J Fungi (Basel). 2021 Oct 14;7(10):
pubmed: 34682283
Angew Chem Int Ed Engl. 2007;46(30):5670-703
pubmed: 17585397
Carbohydr Polym. 2013 Feb 15;92(2):1012-7
pubmed: 23399122
Macromol Biosci. 2009 Sep 9;9(9):884-94
pubmed: 19422013
Int J Pharm. 2021 Nov 20;609:121132
pubmed: 34563618
Int J Mol Sci. 2016 Sep 13;17(9):
pubmed: 27649147
Bioeng Transl Med. 2021 Sep 16;7(1):e10254
pubmed: 35111951
Molecules. 2023 Apr 11;28(8):
pubmed: 37110618
Sci Rep. 2022 Aug 16;12(1):13899
pubmed: 35974115
DNA Res. 2017 Apr 1;24(2):103-115
pubmed: 28431016
Angew Chem Int Ed Engl. 2013 Feb 4;52(6):1636-53
pubmed: 23255416
Int J Nanomedicine. 2017 Mar 21;12:2205-2213
pubmed: 28356737