Placental Infection Associated with SARS-CoV-2 Wildtype Variant and Variants of Concern.
SARS-CoV-2
SARS-CoV-2 variants of concern
pregnancy
waves of COVID-19
Journal
Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722
Informations de publication
Date de publication:
13 Sep 2023
13 Sep 2023
Historique:
received:
11
08
2023
revised:
04
09
2023
accepted:
09
09
2023
medline:
28
9
2023
pubmed:
28
9
2023
entrez:
28
9
2023
Statut:
epublish
Résumé
The original SARS-CoV-2 lineages have been replaced by successive variants of concern (VOCs) over time. The aim of this study was to perform an assessment of the placental infection by SARS-CoV-2 according to the predominant variant at the moment of COVID-19 diagnosis. This was a prospective study of SARS-CoV-2-positive pregnant women between March 2020 and March 2022. The population was divided into pregnancies affected by COVID-19 disease during 2020 (Pre-VOC group) and pregnancies affected after December 2020 by SARS-CoV-2 variants of concern (VOC group). The presence of virus was assessed by RT-PCR, and the viral variant was determined by whole genome sequencing. A total of 104 placentas were examined, among which 54 cases belonged to the Pre-VOC group and 50 cases belonged to the VOC group. Sixteen positive placental RT-PCR tests for SARS-CoV-2 were reported. The NGS analysis confirmed the SARS-CoV-2 lineage in placenta tissue. All samples corresponded to the Pre-VOC group, whereas no placental presence of SARS-CoV-2 was detected in the VOC group (16, 29.6% vs. 0, 0.0%
Identifiants
pubmed: 37766324
pii: v15091918
doi: 10.3390/v15091918
pmc: PMC10536606
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : FEDER ("Una manera de hacer Europa, Construyendo Europa desde Aragón"/European Social Funds)
ID : 277B05_17D
Organisme : Government of Aragon
ID : (LMP228_21 (2022-2023))
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