GABA
BOLD signal
GABAA receptor
[11C]flumazenil
binding potential
emotion
simultaneous fMRI/PET
Journal
Frontiers in neuroscience
ISSN: 1662-4548
Titre abrégé: Front Neurosci
Pays: Switzerland
ID NLM: 101478481
Informations de publication
Date de publication:
2023
2023
Historique:
received:
25
08
2022
accepted:
16
08
2023
medline:
28
9
2023
pubmed:
28
9
2023
entrez:
28
9
2023
Statut:
epublish
Résumé
The fMRI BOLD response to emotional stimuli highlighting the role of the medial prefrontal cortex (MPFC) has been thoroughly investigated. Recently, the relationship between emotion processing and GABA levels has been studied using MPFC proton magnetic resonance spectroscopy (1H-MRS). However, the role of GABAA receptors in the MPFC during emotion processing remains unexplored. Using [11C]flumazenil PET, we investigated the relationship between the binding potential of GABAA receptors and emotion processing as measured using simultaneous fMRI BOLD. We hypothesized a correlation between the percent signal change in the BOLD signal and the binding potential of GABAA receptors in the MPFC. In a combined simultaneous fMRI and [11C]flumazenil-PET study, we analyzed the data from 15 healthy subjects using visual emotional stimuli. Our task comprised two types of emotional processing: passive viewing and appraisal. Following the administration of a bolus plus infusion protocol, PET and fMRI data were simultaneously acquired in a hybrid 3 T MR-BrainPET. We found a differential correlation of BOLD percent signal change with [11C]flumazenil binding potential in the MPFC. Specifically, [11C]flumazenil binding potential in the ventromedial prefrontal cortex (vMPFC) correlated with passive viewing of emotionally valenced pictures. In contrast, the [11C]flumazenil binding potential and the BOLD signal induced by picture appraisal did show a correlation in the paracingulate gyrus. Our data deliver first evidence for a relationship between MPFC GABAA receptors and emotion processing in the same region. Moreover, we observed that GABAA receptors appear to play different roles in emotion processing in the vMPFC (passive viewing) and paracingulate gyrus (appraisal).
Identifiants
pubmed: 37766785
doi: 10.3389/fnins.2023.1027697
pmc: PMC10520870
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1027697Informations de copyright
Copyright © 2023 Heinzel, Mauler, Herzog, Boers, Mottaghy, Langen, Scheins, Lerche, Neumaier, Northoff and Shah.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
J Neurosci. 2011 Oct 5;31(40):14308-13
pubmed: 21976516
Phys Med Biol. 2015 Dec 21;60(24):9349-75
pubmed: 26579597
Hum Brain Mapp. 2014 Jan;35(1):173-84
pubmed: 22996793
J Pers Soc Psychol. 1988 Jun;54(6):1063-70
pubmed: 3397865
Biomed Res Int. 2016;2016:9132840
pubmed: 27123457
Psychiatry Res Neuroimaging. 2021 Sep 30;315:111327
pubmed: 34246046
Am J Psychiatry. 2015 Nov 1;172(11):1148-59
pubmed: 26133962
Vis Neurosci. 2008 Jan-Feb;25(1):17-26
pubmed: 18282307
CNS Spectr. 2004 Apr;9(4):258-66
pubmed: 15048050
Cereb Cortex. 2004 Apr;14(4):424-31
pubmed: 15028646
Brain Res Cogn Brain Res. 2005 Sep;25(1):348-58
pubmed: 16081255
Behav Res Methods. 2007 May;39(2):326-34
pubmed: 17695361
Neuroimage. 2002 Jun;16(2):331-48
pubmed: 12030820
Neuroimage. 2003 Jul;19(3):1049-60
pubmed: 12880831
eNeuro. 2019 Jul 25;6(4):
pubmed: 31289107
J Clin Psychiatry. 1998;59 Suppl 20:22-33;quiz 34-57
pubmed: 9881538
ACS Chem Neurosci. 2020 Jul 15;11(14):2039-2044
pubmed: 32578977
IEEE Trans Med Imaging. 2011 Mar;30(3):879-92
pubmed: 21292592
J Cereb Blood Flow Metab. 2008 Mar;28(3):579-87
pubmed: 17928801
Nervenarzt. 2007 Jun;78(6):651-6
pubmed: 16832698
Hum Brain Mapp. 2004 Mar;21(3):202-12
pubmed: 14755839
PLoS One. 2016 Feb 04;11(2):e0147932
pubmed: 26845028
Behav Res Methods. 2008 May;40(2):512-21
pubmed: 18522062
Neuroimage. 2006 Mar;30(1):325-40
pubmed: 16230029
Front Neurosci. 2011 Jun 03;5:77
pubmed: 21687799
Nuklearmedizin. 2011;50(2):74-82
pubmed: 21286660
Neuroimage. 2017 Sep;158:136-144
pubmed: 28669913
Front Psychiatry. 2021 Mar 08;12:644315
pubmed: 33762983
Eur J Nucl Med Mol Imaging. 2009 Apr;36(4):659-70
pubmed: 19043703
Commun Biol. 2018 Jun 7;1:62
pubmed: 30271944
Cogn Neurosci. 2016 Jan-Oct;7(1-4):203-22
pubmed: 26505808
Neurosci Biobehav Rev. 2014 Sep;45:350-68
pubmed: 25010558
Neuroimage. 2012 Aug 15;62(2):1040-50
pubmed: 22261372
Neuroimage. 2006 Jul 1;31(3):968-80
pubmed: 16530430
Neuroimage. 1995 Jun;2(2):157-65
pubmed: 9343598
J Neurosci Methods. 2014 Jan 15;221:183-8
pubmed: 24459715
Hum Brain Mapp. 2001 Dec;14(4):228-35
pubmed: 11668654
Eur J Nucl Med Mol Imaging. 2010 Mar;37(3):565-74
pubmed: 19890631
Neuroscience. 2018 May 21;379:142-151
pubmed: 29530810
Psychother Psychosom Med Psychol. 1996 Jan;46(1):23-8
pubmed: 8850096
Brain Struct Funct. 2020 Jan;225(1):345-363
pubmed: 31863185
Neurosci Biobehav Rev. 2014 Nov;47:36-52
pubmed: 25066091
Sci Rep. 2019 Feb 14;9(1):2116
pubmed: 30765822
Nat Commun. 2015 Nov 17;6:8956
pubmed: 26573408
J Magn Reson Imaging. 2019 Oct;50(4):1285-1294
pubmed: 30873721
Neuropsychopharmacology. 2013 Jul;38(8):1438-50
pubmed: 23389691
Psych J. 2016 Jun;5(2):117-24
pubmed: 27256203
Cereb Cortex. 2021 Jul 29;31(9):4053-4067
pubmed: 33895810
Neuroimage. 2020 Nov 1;221:117160
pubmed: 32679251
Behav Brain Res. 2022 Feb 15;419:113663
pubmed: 34780857
Neuroimage. 1996 Dec;4(3 Pt 1):153-8
pubmed: 9345505
J Cereb Blood Flow Metab. 1991 Sep;11(5):735-44
pubmed: 1651944
Eur J Pharmacol. 1992 Mar 17;213(1):107-15
pubmed: 1323469
J Cereb Blood Flow Metab. 1992 Sep;12(5):709-16
pubmed: 1506439