Defining the clinical characteristics of mammary analog secretory carcinoma of the salivary gland: Analysis of the National Cancer Database.

Mammary analog secretory carcinoma head and neck neoplasms mouth neoplasms salivary gland neoplasms

Journal

SAGE open medicine
ISSN: 2050-3121
Titre abrégé: SAGE Open Med
Pays: England
ID NLM: 101624744

Informations de publication

Date de publication:
2023
Historique:
received: 21 02 2023
accepted: 23 08 2023
medline: 28 9 2023
pubmed: 28 9 2023
entrez: 28 9 2023
Statut: epublish

Résumé

Mammary analog secretory carcinoma (MASC) is a classification of salivary gland tumors, recently included within the term secretory carcinoma. Previous descriptions of this diagnosis have largely consisted of case reports and case series with few studies investigating its clinical characteristics as compared to non-MASC tumors. Our objective was to use a large patient database to compare the clinical characteristics of mammary analog secretory carcinoma vs. non-mammary analog secretory carcinoma salivary gland tumors. The National Cancer Database was queried between September and October 2022 for histological diagnosis of mammary analog secretory carcinoma and non-MASC salivary tumors. Patients diagnosed with mammary analog secretory carcinoma and non-mammary analog secretory carcinoma salivary tumors between the period of 2004 through 2019 were included in this analysis. Various demographic and clinical variables were abstracted from the database and compared using Wilcoxon rank sum and chi-square tests. Survival was compared between cohorts using Cox proportional hazards regression. Overall, compared to non-mammary analog secretory carcinoma diagnoses ( Clinically, mammary analog secretory carcinoma salivary tumors have a more indolent course compared to other salivary cancers. Additional studies are needed to determine the natural history of this tumor type.

Identifiants

pubmed: 37767536
doi: 10.1177/20503121231200103
pii: 10.1177_20503121231200103
pmc: PMC10521276
doi:

Types de publication

Journal Article

Langues

eng

Pagination

20503121231200103

Informations de copyright

© The Author(s) 2023.

Déclaration de conflit d'intérêts

The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

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Auteurs

Akshilkumar Patel (A)

The Pennsylvania State University College of Medicine, Hershey, PA, USA.

Brandon LaBarge (B)

Department of Otolaryngology-Head and Neck Surgery, Penn State Health Milton S. Hershey Medical Center, Hershey, PA, USA.

Tonya S King (TS)

Department of Public Health Sciences, The Pennsylvania State University College of Medicine, Hershey, PA, USA.

Sandeep Pradhan (S)

Department of Public Health Sciences, The Pennsylvania State University College of Medicine, Hershey, PA, USA.

Joshua Warrick (J)

Department of Pathology and Laboratory Medicine, Penn State Health Milton S. Hershey Medical Center, Hershey, PA, USA.

Neerav Goyal (N)

Department of Otolaryngology-Head and Neck Surgery, Penn State Health Milton S. Hershey Medical Center, Hershey, PA, USA.

Classifications MeSH