Effect of kava (Piper methysticum) on peripheral gene expression among individuals with generalized anxiety disorder: A post hoc analysis of a randomized controlled trial.
gene expression
generalized anxiety disorder
kava
Journal
Phytotherapy research : PTR
ISSN: 1099-1573
Titre abrégé: Phytother Res
Pays: England
ID NLM: 8904486
Informations de publication
Date de publication:
Dec 2023
Dec 2023
Historique:
revised:
23
06
2023
received:
20
12
2022
accepted:
17
08
2023
pubmed:
28
9
2023
medline:
28
9
2023
entrez:
28
9
2023
Statut:
ppublish
Résumé
Kava is a South Pacific plant-based medicine with anxiolytic properties, but little is known about the impact kava has on gene expression or whether gene expression can serve as a marker of kava response. This study aimed to determine whether kava treatment alters the expression of genes with physiological relevance to anxiety pathophysiology and whether the baseline expression of these physiologically relevant genes modifies the efficacy of kava treatment. In this post hoc analysis, we examined the expression of 48 genes relevant to the pathophysiology of anxiety collected from a double-blind randomized controlled trial that assessed the efficacy of kava treatment in generalized anxiety disorder. Peripheral blood gene expression was measured in 71 (34 kava, 37 placebo) adults at baseline and in 40 (19 kava, 21 placebo) after 8 weeks of treatment by reverse transcription polymerase chain reaction (PCR). Results revealed that kava decreased the expression of a subunit of the GABA
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
5897-5903Subventions
Organisme : National Health and Medical Research Council
ID : APP1063383
Organisme : Integria Healthcare
Organisme : NHMRC Clinical Research Fellowship
ID : APP1125000
Informations de copyright
© 2023 John Wiley & Sons Ltd.
Références
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