Synthesis, Base Pairing Properties, and Biological Activity Studies of Platinum(II) Complexes Based on Uracil Nucleosides.

Humans Base Pairing Platinum Nucleosides Uridine Uracil / pharmacology Deoxyuridine Hydrogen Bonding

Journal

Inorganic chemistry
ISSN: 1520-510X
Titre abrégé: Inorg Chem
Pays: United States
ID NLM: 0366543

Informations de publication

Date de publication:
09 Oct 2023
Historique:
medline: 10 10 2023
pubmed: 28 9 2023
entrez: 28 9 2023
Statut: ppublish

Résumé

The synthesis and base pairing properties of platinum complexes based on uridine and deoxyuridine nucleosides and preliminary studies of their antiproliferative activity are described. Platinum(II) uridine and deoxyuridine complexes were synthesized by C-I oxidative addition to Pt(0)(PPh

Identifiants

DOI: 10.1021/acs.inorgchem.3c02071 PMID: 37768109
pubmed: 37768109
doi: 10.1021/acs.inorgchem.3c02071
doi:

Substances chimiques

Platinum 49DFR088MY
Nucleosides 0
Uridine WHI7HQ7H85
Uracil 56HH86ZVCT
Deoxyuridine W78I7AY22C

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

16412-16425

Auteurs

Maria Inês P S Leitão (MIPS)

Instituto de Tecnologia Química e Biológica António Xavier, Av. da Republica, 2780-157 Oeiras, Portugal.

Giulia Orsini (G)

Instituto de Tecnologia Química e Biológica António Xavier, Av. da Republica, 2780-157 Oeiras, Portugal.

Fernanda Murtinheira (F)

BioISI - Instituto de Biosistemas e Ciências Integrativas, Dep. Química e Bioquímica, Faculdade de Ciências da Universidade de Lisboa, Campo Grande, 1749-016 Lisboa, Portugal.

Clara S B Gomes (CSB)

LAQV-REQUIMTE, Departamento de Química, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, 2829-516 Caparica, Portugal.
UCIBIO and i4HB - Applied Molecular Biosciences Unit and Institute for Health and Bioeconomy, Departamento de Química, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, 2829-516 Caparica, Portugal.
ORCID: 0000-0003-3672-0045

Federico Herrera (F)

BioISI - Instituto de Biosistemas e Ciências Integrativas, Dep. Química e Bioquímica, Faculdade de Ciências da Universidade de Lisboa, Campo Grande, 1749-016 Lisboa, Portugal.

Ana Petronilho (A)

Instituto de Tecnologia Química e Biológica António Xavier, Av. da Republica, 2780-157 Oeiras, Portugal.
ORCID: 0000-0002-3296-1522

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Synthesis, Base Pairing Properties, and...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Conformation d'acide nucléique › Appariement de bases › Synthesis, Base Pairing Properties, and...
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux lourds › Platine › Synthesis, Base Pairing Properties, and...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléosides › Synthesis, Base Pairing Properties, and...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléosides › Ribonucléosides › Uridine › Synthesis, Base Pairing Properties, and...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyrimidines › Pyrimidinones › Uracile › Synthesis, Base Pairing Properties, and...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléosides › Nucléosides pyrimidiques › Désoxyuridine › Synthesis, Base Pairing Properties, and...
questionsmedicales.fr › Phénomènes chimiques › Liaison hydrogène › Synthesis, Base Pairing Properties, and...