Changes in the Number of Residual γH2AX Foci in Ki-67-Positive and Ki-67-Negative Human Fibroblasts Irradiated with X-Rays in Doses of 2-10 Gy.
DNA double-strand breaks
X-ray radiation
cell proliferation
human fibroblasts
residual γH2AX foci
Journal
Bulletin of experimental biology and medicine
ISSN: 1573-8221
Titre abrégé: Bull Exp Biol Med
Pays: United States
ID NLM: 0372557
Informations de publication
Date de publication:
Aug 2023
Aug 2023
Historique:
received:
28
10
2022
medline:
9
10
2023
pubmed:
28
9
2023
entrez:
28
9
2023
Statut:
ppublish
Résumé
We studied changes in the number of residual γH2AX foci in cultured human fibroblasts with different expression of the cell proliferation marker protein Ki-67 24, 48, and 72 h after exposure to X-ray radiation in doses of 2-10 Gy. It was shown that, regardless of the expression of Ki-67, the number of residual γH2AX foci in irradiated cells linearly depends on the absorbed dose of X-ray radiation. However, the quantitative yield of residual γH2AX foci per unit of the absorbed dose in Ki-67
Identifiants
pubmed: 37768460
doi: 10.1007/s10517-023-05883-2
pii: 10.1007/s10517-023-05883-2
doi:
Substances chimiques
Ki-67 Antigen
0
Histones
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
450-453Informations de copyright
© 2023. Springer Science+Business Media, LLC, part of Springer Nature.
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