Dissociative Electron Attachment to 5-Iodo-4-thio-2'-deoxyuridine: A Potential Radiosensitizer of Hypoxic Cells.
Journal
The journal of physical chemistry letters
ISSN: 1948-7185
Titre abrégé: J Phys Chem Lett
Pays: United States
ID NLM: 101526034
Informations de publication
Date de publication:
12 Oct 2023
12 Oct 2023
Historique:
medline:
23
10
2023
pubmed:
28
9
2023
entrez:
28
9
2023
Statut:
ppublish
Résumé
In the search for effective radiosensitizers for tumor cells, halogenated uracils have attracted more attention due to their large cross section for dissociation upon the attachment of low-energy electrons. In this study, we investigated dissociative electron attachment (DEA) to 5-iodo-4-thio-2'-deoxyuridine, a potential radiosensitizer using a crossed electron-molecule beam experiment coupled with quadrupole mass spectrometry. The experimental results were supported by calculations on the threshold energies of formed anions and transition state calculations. We show that low-energy electrons with kinetic energies near 0 eV may effectively decompose the molecule upon DEA. The by far most abundant anion observed corresponds to the iodine anion (I
Identifiants
pubmed: 37769041
doi: 10.1021/acs.jpclett.3c02219
pmc: PMC10578351
doi:
Substances chimiques
4-thio-2'-deoxyuridine
5580-20-1
Radiation-Sensitizing Agents
0
Thiouridine
13957-31-8
Anions
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
8948-8955Références
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