"Dominolike" Barriers Elimination with an Intratumoral Adenosine-Triphosphate-Supersensitive Nanogel to Enhance Cancer Chemoimmunotherapy.

Humans Nanogels Neoplasms / drug therapy Immunotherapy Adenosine Triphosphate Adenosine Tumor Microenvironment Cell Line, Tumor
ATP supersensitive CXCR4/CXCL12 axis cancer chemoimmunotherapy deep penetration tumor-associated macrophages (TAMs)

Journal

ACS nano
ISSN: 1936-086X
Titre abrégé: ACS Nano
Pays: United States
ID NLM: 101313589

Informations de publication

Date de publication:
10 10 2023
Historique:
medline: 11 10 2023
pubmed: 29 9 2023
entrez: 28 9 2023
Statut: ppublish

Résumé

Pathophysiological barriers in "cold" tumors seriously limit the clinical outcomes of chemoimmunotherapy. These barriers distribute in a spatial order in tumors, including immunosuppressive microenvironment, overexpressed chemokine receptors, and dense tumor mesenchyme, which require a sequential elimination in therapeutics. Herein, we reported a "dominolike" barriers elimination strategy by an intratumoral ATP supersensitive nanogel (denoted as B

Identifiants

DOI: 10.1021/acsnano.3c03386 PMID: 37769188
pubmed: 37769188
doi: 10.1021/acsnano.3c03386
doi:

Substances chimiques

polyethylene glycol polyethyleneimine nanogel 0
Nanogels 0
triphosphoric acid NU43IAG5BC
Adenosine Triphosphate 8L70Q75FXE
Adenosine K72T3FS567

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

18805-18817

Auteurs

Feiran Zhang (F)

State Key Laboratory of Natural Medicines and Department of Pharmaceutics, China Pharmaceutical University, Nanjing, Jiangsu 210009, China.
Nanjing Branch, Jiangsu Yuanchuang Pharmaceutical Research and Development Co., Ltd., Nanjing, Jiangsu 210000, China.

Jingwen Dong (J)

State Key Laboratory of Natural Medicines and Department of Pharmaceutics, China Pharmaceutical University, Nanjing, Jiangsu 210009, China.

Kan Huang (K)

State Key Laboratory of Natural Medicines and Department of Pharmaceutics, China Pharmaceutical University, Nanjing, Jiangsu 210009, China.

Bowen Duan (B)

State Key Laboratory of Natural Medicines and Department of Pharmaceutics, China Pharmaceutical University, Nanjing, Jiangsu 210009, China.

Chenzi Li (C)

State Key Laboratory of Natural Medicines and Department of Pharmaceutics, China Pharmaceutical University, Nanjing, Jiangsu 210009, China.

Ruoxi Yang (R)

State Key Laboratory of Natural Medicines and Department of Pharmaceutics, China Pharmaceutical University, Nanjing, Jiangsu 210009, China.

Jing Li (J)

State Key Laboratory of Natural Medicines and Department of Pharmaceutics, China Pharmaceutical University, Nanjing, Jiangsu 210009, China.

Feng Zhi (F)

Department of Neurosurgery, The First People's Hospital of Changzhou, Changzhou, Jiangsu 213000, China.

Zhanwei Zhou (Z)

State Key Laboratory of Natural Medicines and Department of Pharmaceutics, China Pharmaceutical University, Nanjing, Jiangsu 210009, China.
ORCID: 0000-0002-7149-3223

Minjie Sun (M)

State Key Laboratory of Natural Medicines and Department of Pharmaceutics, China Pharmaceutical University, Nanjing, Jiangsu 210009, China.
ORCID: 0000-0003-0582-6189

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › "Dominolike" Barriers Elimination with an...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Nanostructures › Nanoparticules › Nanogels › "Dominolike" Barriers Elimination with an...
questionsmedicales.fr › Tumeurs › "Dominolike" Barriers Elimination with an...
questionsmedicales.fr › Thérapeutique › Biothérapie › Immunothérapie › "Dominolike" Barriers Elimination with an...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Ribonucléotides › Nucléotides adényliques › Adénosine triphosphate › "Dominolike" Barriers Elimination with an...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléosides › Ribonucléosides › Adénosine › "Dominolike" Barriers Elimination with an...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Microenvironnement cellulaire › Microenvironnement tumoral › "Dominolike" Barriers Elimination with an...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › "Dominolike" Barriers Elimination with an...