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Journal

Journal of nuclear medicine : official publication, Society of Nuclear Medicine
ISSN: 1535-5667
Titre abrégé: J Nucl Med
Pays: United States
ID NLM: 0217410

Informations de publication

Date de publication:
01 Dec 2023
Historique:
received: 13 01 2023
revised: 24 05 2023
medline: 4 12 2023
pubmed: 29 9 2023
entrez: 28 9 2023
Statut: epublish

Résumé

Poly(adenosine diphosphate ribose) polymerase (PARP) has emerged as an effective therapeutic strategy against cancer that targets the DNA damage repair enzyme. PARP-targeting compounds radiolabeled with an Auger electron-emitting radionuclide can be trapped close to damaged DNA in tumor tissue, where high ionizing potential and short range lead Auger electrons to kill cancer cells through the creation of complex DNA damage, with minimal damage to surrounding normal tissue. Here, we report on [

Identifiants

pubmed: 37770109
pii: jnumed.123.265429
doi: 10.2967/jnumed.123.265429
pmc: PMC10690119
doi:

Substances chimiques

Poly(ADP-ribose) Polymerase Inhibitors 0
Radiopharmaceuticals 0
Iodine-123 8YWR746RPQ

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1965-1971

Informations de copyright

© 2023 by the Society of Nuclear Medicine and Molecular Imaging.

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Auteurs

Chung Ying Chan (CY)

MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, United Kingdom.

Zijun Chen (Z)

Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford, United Kingdom; and.

Florian Guibbal (F)

MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, United Kingdom.

Gemma Dias (G)

MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, United Kingdom.

Gianluca Destro (G)

MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, United Kingdom.
Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford, United Kingdom; and.

Edward O'Neill (E)

MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, United Kingdom.

Mathew Veal (M)

MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, United Kingdom.

Doreen Lau (D)

MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, United Kingdom.

Michael Mosley (M)

MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, United Kingdom.

Thomas C Wilson (TC)

Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford, United Kingdom; and.

Véronique Gouverneur (V)

Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford, United Kingdom; and.

Bart Cornelissen (B)

MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, United Kingdom; bart.cornelissen@oncology.ox.ac.uk.
Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

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Classifications MeSH